Glutathione S-transferase polymorphisms in patients with photosensitive and non-photosensitive drug eruptions

Tal Ben Ami, Ofer Sarig, Eli Sprecher, Ilan Goldberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Glutathione S-transferases (GSTs) play a critical role in cellular protection against oxidative damage. Polymorphisms in three major GST loci have been described. A number of studies have looked for an association between GSTs and skin diseases. Purpose: To ascertain the possibility that polymorphisms in the GSTM1, GSTT1, and GSTP1 genes may predict the development of photo-induced and non-photo-induced drug eruptions. Methods: A cohort of 40 patients with drug eruptions, 10 of whom had developed a photo-induced drug reaction, and matched controls (116 for GSTM1 and GSTT1, 120 for GSTP1) were studied. Genotyping was conducted using direct sequencing and polymerase chain reaction. Results: The GSTP1 Val/Val genotype was significantly associated with non-photosensitive drug eruptions (OR = 3.64, P value = 0.038), whereas associations observed between GSTP1, GSTM1, GSTT1 polymorphisms and photosensitive drug eruptions did not reach statistical significance. Conclusions: Variations in GSTP1 may affect the risk to develop non-photo-induced drug eruptions. These results warrant confirmatory studies in a larger patient sample.

Original languageEnglish
Pages (from-to)214-220
Number of pages7
JournalPhotodermatology Photoimmunology and Photomedicine
Volume35
Issue number4
DOIs
StatePublished - Jul 2019

Funding

FundersFunder number
Tel Aviv Sourasky Medical Center

    Keywords

    • drug eruptions
    • genetic polymorphisms
    • glutathione S-transferases
    • photosensitive drug eruptions
    • photosensitivity

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