TY - JOUR
T1 - Glutathione-S-transferase and drug metabolism in Trypanosoma cruzi
T2 - In Vivo and in vitro formation of thioethers
AU - Yawetz, Aminadav
AU - Agosin, Moises
N1 - Funding Information:
* Supportedin part by NIH Public Health Service Grant AI-12244.
PY - 1980
Y1 - 1980
N2 - 1. The epimastigotes of Trypanosoma cruzi catalyze in vivo and in vitro the conjugation of styrene oxide and 1-chloro-2,4-dinitrobenzene at substantial rates. 2. Conjugation of drugs possessing an electrophilic grouping to the thiol group of glutathione may represent an important detoxication factor in the resistance of the parasite to known antiprotozoal agents.
AB - 1. The epimastigotes of Trypanosoma cruzi catalyze in vivo and in vitro the conjugation of styrene oxide and 1-chloro-2,4-dinitrobenzene at substantial rates. 2. Conjugation of drugs possessing an electrophilic grouping to the thiol group of glutathione may represent an important detoxication factor in the resistance of the parasite to known antiprotozoal agents.
UR - http://www.scopus.com/inward/record.url?scp=0018933596&partnerID=8YFLogxK
U2 - 10.1016/0306-4492(80)90138-0
DO - 10.1016/0306-4492(80)90138-0
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AN - SCOPUS:0018933596
SN - 0306-4492
VL - 66
SP - 265
EP - 267
JO - Comparative biochemistry and physiology. C: Comparative pharmacology
JF - Comparative biochemistry and physiology. C: Comparative pharmacology
IS - 2
ER -