Glutathione-S-transferase and drug metabolism in Trypanosoma cruzi: In Vivo and in vitro formation of thioethers

Aminadav Yawetz, Moises Agosin

Research output: Contribution to journalArticlepeer-review

Abstract

1. The epimastigotes of Trypanosoma cruzi catalyze in vivo and in vitro the conjugation of styrene oxide and 1-chloro-2,4-dinitrobenzene at substantial rates. 2. Conjugation of drugs possessing an electrophilic grouping to the thiol group of glutathione may represent an important detoxication factor in the resistance of the parasite to known antiprotozoal agents.

Original languageEnglish
Pages (from-to)265-267
Number of pages3
JournalComparative biochemistry and physiology. C: Comparative pharmacology
Volume66
Issue number2
DOIs
StatePublished - 1980
Externally publishedYes

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