Glutathione IX. New thiol-oxidizing agents: DIP, DIP+1, DIP+2

Edward M. Kosower*, Nechama S. Kosower, Hanna Kenety-Londner, Lilly Levy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


New thiol-oxidizing agents, DIP (diazene dicarboxylic acid bis(N′-methylpiperazide), DIP+1(N′-methyl iodide salt of DIP), and DIP+2 (bis-N′-methyl iodide salt of DIP) have been applied to human red blood cell suspensions. At 20°C, DIP leads to fairly rapid oxidation of intracellular glutathione, GSH. Although both DIP+1 and DIP+2 are slightly more reactive towards GSH than DIP, neither agent causes any change in intracellular GSH. Possible applications of the new series are outlined.

Original languageEnglish
Pages (from-to)347-351
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - 10 Jul 1974


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