TY - JOUR
T1 - Glutathione IX. New thiol-oxidizing agents
T2 - DIP, DIP+1, DIP+2
AU - Kosower, Edward M.
AU - Kosower, Nechama S.
AU - Kenety-Londner, Hanna
AU - Levy, Lilly
N1 - Funding Information:
ACKNOWLEDGEMENT: Supported in part by a grant from the Chief Scientist's Office, Ministry of Health, Government of Israel.
PY - 1974/7/10
Y1 - 1974/7/10
N2 - New thiol-oxidizing agents, DIP (diazene dicarboxylic acid bis(N′-methylpiperazide), DIP+1(N′-methyl iodide salt of DIP), and DIP+2 (bis-N′-methyl iodide salt of DIP) have been applied to human red blood cell suspensions. At 20°C, DIP leads to fairly rapid oxidation of intracellular glutathione, GSH. Although both DIP+1 and DIP+2 are slightly more reactive towards GSH than DIP, neither agent causes any change in intracellular GSH. Possible applications of the new series are outlined.
AB - New thiol-oxidizing agents, DIP (diazene dicarboxylic acid bis(N′-methylpiperazide), DIP+1(N′-methyl iodide salt of DIP), and DIP+2 (bis-N′-methyl iodide salt of DIP) have been applied to human red blood cell suspensions. At 20°C, DIP leads to fairly rapid oxidation of intracellular glutathione, GSH. Although both DIP+1 and DIP+2 are slightly more reactive towards GSH than DIP, neither agent causes any change in intracellular GSH. Possible applications of the new series are outlined.
UR - http://www.scopus.com/inward/record.url?scp=0016389164&partnerID=8YFLogxK
U2 - 10.1016/S0006-291X(74)80213-5
DO - 10.1016/S0006-291X(74)80213-5
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AN - SCOPUS:0016389164
SN - 0006-291X
VL - 59
SP - 347
EP - 351
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -