Glucose-induced dysmorphogenesis in the cultured rat conceptus: Prevention by supplementation with myo-inositol

M. Hod, S. Star, J. Passonneau, T. G. Unterman, N. Freinkel

Research output: Contribution to journalArticlepeer-review

Abstract

Growth retardation and dysmorphogenesis in the rat conceptus are accompanied by diminished tissue myo-inositol following culture from day 9.5 to 11.5 of development in the presence of increased amounts of glucose. Reductions of myo-inositol and increased malformations are not corrected by aldose reductase inhibitors. In contrast, supplementation of culture medium with myo-inositol (1.5 mg/ml) restores tissue myo-inositol content, lowers the incidence of dysmorphogenic embryos (from 51.1 to 28.6%, P<0.001) and reduces the incidence of neural tube defects to control levels (from 33.3 to 6%, P<0.001). These results suggest that myo-inositol depletion is involved in the mechanism of diabetic embryopathy.

Original languageEnglish
Pages (from-to)541-544
Number of pages4
JournalIsrael Journal of Medical Sciences
Volume26
Issue number10
StatePublished - 1990
Externally publishedYes

Keywords

  • Hyperglycemia
  • birth defects
  • diabetes mellitus
  • inositol
  • teratogenesis

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