Glucose-functionalized gold nanoparticles as a metabolically targeted CT contrast agent for distinguishing tumors from non-malignant metabolically active processes

Tamar Dreifuss, Menachem Motiei, Oshra Betzer, Aron Popovtzer, Galith Abourbeh, Eyal Mishani, Rachela Popovtzer

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The highly used cancer imaging technique, [18F]FDG-PET, is based on the increased glucose metabolic activity in tumors. However, since there are other biological processes that exhibit increased metabolic activity, in particular inflammation, this methodology is prone to non-specificity for cancer. Herein we describe the development of a novel nanoparticle-based approach, utilizes Glucose-Functionalized Gold Nanoparticles (GF-GNPs) as a metabolically targeted CT contrast agent. Our method has demonstrated specific tumor targeting and has successfully differentiated between cancer and inflammation in a combined tumor-inflammation mouse model, due to dissimilarities in vasculatures in different pathologic conditions. This novel approach provides new capabilities in cancer imaging, and can be applicable to a wide range of cancers.

Original languageEnglish
Title of host publicationNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV
EditorsDan V. Nicolau, Dror Fixler, Alexander N. Cartwright
PublisherSPIE
ISBN (Electronic)9781510605954
DOIs
StatePublished - 2017
Externally publishedYes
EventNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV 2017 - San Francisco, United States
Duration: 30 Jan 20171 Feb 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10077
ISSN (Print)1605-7422

Conference

ConferenceNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIV 2017
Country/TerritoryUnited States
CitySan Francisco
Period30/01/171/02/17

Keywords

  • CT
  • Cancer
  • FDG-PET
  • Gold nanoparticles
  • Metabolic-based imaging

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