Glucose correlation with light scattering patterns - A novel method for non-invasive glucose measurements

Ohad Cohen, Ilya Fine, Emanuel Monashkin, Avraham Karasik

Research output: Contribution to journalArticlepeer-review

Abstract

To correlate occlusion red near-infrared spectroscopy technology with intravenous and interstitial glucose levels, occlusion red near-infrared spectroscopy and glucose levels were measured in five subjects with diabetes mellitus during a stepped hyperinsulinemic hypoglycemic clamp. Validation was achieved using a standard error grid and linear correlations. During hyperinsulinemic hypoglycemic clamp linear correlation was significant at r = 0.836, and the intercept was 43.3 mg/dL. Of the glucose measurements, 94.3% were assigned to zones A and B of the standard error grid, the zones of the greatest therapeutic relevance. Expected interference from serum triglycerides, catecholamines, and cortisol was not apparent. These results demonstrate the applicability of occlusion red near-infrared spectroscopy for in vivo glucose monitoring. The technology has implications for continuous non-invasive glucose sensing.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalDiabetes Technology and Therapeutics
Volume5
Issue number1
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

Dive into the research topics of 'Glucose correlation with light scattering patterns - A novel method for non-invasive glucose measurements'. Together they form a unique fingerprint.

Cite this