Glucose and insulin metabolism are important determinants of left ventricular mass in obese hypertensives

R. Kuperstein, Z. Sasson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Obesity and hypertension, the major modifiable clinical determinants of left ventricular mass, are both associated with a state of insulin resistance. Objective: To determine the relationships between glucose and insulin metabolism and left ventricular mass in a group of obese, nondiabetic, hypertensive people. Patients and methods: Twenty-two obese, nondiabetic, hypertensive people (10 men), free of coronary or valvular heart disease, with normal left ventricular function were studied. The mean age was 55±12 years, body mass index 32.8±4.8 kg/m2, and systolic and diastolic blood pressures 149.0±11.0 mmHg and 98.0±4.0 mmHg, respectively. Left ventricular mass corrected for height (LVM/Ht) and glucose and insulin metabolism (3 h intravenous glucose tolerance test) were measured after a four- to six-week washout period of any antihypertensive medication. Results: The mean LVM/Ht was 119.5±11.9 kg/m. The following metabolic measures correlated with LVM/Ht in a univariate analysis: total insulin integration area (r=0.54, P=0.008); fasting insulin (r=0.43, P=0.04); insulin at 90 min (r=0.54, P=0.013); and peak glucose levels (r=0.51, P=0.013). Stepwise multivariate linear regression analysis showed that only total insulin integration area (P=0.005) and peak glucose levels (P=0.01) correlated with LVM/Ht. Conclusion: In obese, nondiabetic, hypertensive people, left ventricular mass is associated with circulating glucose and insulin levels.

Original languageEnglish
Pages (from-to)1103-1108
Number of pages6
JournalCanadian Journal of Cardiology
Volume16
Issue number9
StatePublished - 2000
Externally publishedYes

Keywords

  • Hypertension
  • Insulin
  • Left ventricle
  • Obesity

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