Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors

Michal Rivlin; Gil Navon

doi:10.1038/srep32648

Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors

Michal Rivlin, Gil Navon^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The efficacy of glucosamine (GlcN) and N-acetyl glucosamine (GlcNAc) as agents for chemical exchange saturation transfer (CEST) magnetic resonance molecular imaging of tumors is demonstrated. Both agents reflect the metabolic activity and malignancy of the tumors. The method was tested in two types of tumors implanted orthotopically in mice: 4T 1 (mouse mammary cancer cells) and MCF7 (human mammary cancer cells). 4T 1 is a more aggressive type of tumor than MCF7 and exhibited a larger CEST effect. Two methods of administration of the agents, intravenous (IV) and oral (PO), gave similar results. The CEST MRI observation of lung metastasis was confirmed by histology. The potential of the clinical application of CEST MRI with these agents for cancer diagnosis is strengthened by their lack of toxicity as can be indicated from their wide use as food supplements.

Original language	English
Article number	32648
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep32648
State	Published - 7 Sep 2016

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abstract = "The efficacy of glucosamine (GlcN) and N-acetyl glucosamine (GlcNAc) as agents for chemical exchange saturation transfer (CEST) magnetic resonance molecular imaging of tumors is demonstrated. Both agents reflect the metabolic activity and malignancy of the tumors. The method was tested in two types of tumors implanted orthotopically in mice: 4T 1 (mouse mammary cancer cells) and MCF7 (human mammary cancer cells). 4T 1 is a more aggressive type of tumor than MCF7 and exhibited a larger CEST effect. Two methods of administration of the agents, intravenous (IV) and oral (PO), gave similar results. The CEST MRI observation of lung metastasis was confirmed by histology. The potential of the clinical application of CEST MRI with these agents for cancer diagnosis is strengthened by their lack of toxicity as can be indicated from their wide use as food supplements.",

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Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors

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