TY - JOUR
T1 - Glucagon like peptide-1 (GLP-1) agonists and cardiometabolic protection
T2 - historical development and future challenges
AU - Westermeier, Francisco
AU - Fisman, Enrique Z.
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have revolutionized the treatment of cardiometabolic diseases, extending their therapeutic applications far beyond glycemic control in type 2 diabetes (T2D) and obesity. This editorial synthesizes key milestones, from the discovery of GLP-1 to recent clinical trials highlighting the pleiotropic effects of GLP-1RAs in addressing the interconnected spectrum of cardiometabolic conditions, with a focus on cardiovascular, renal, and hepatic benefits. In addition, as GLP-1RAs continue to reshape the management of cardiometabolic disease and global public health, we discuss future challenges to better elucidate their mechanisms of cardiometabolic protection and maximize their therapeutic potential.
AB - Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have revolutionized the treatment of cardiometabolic diseases, extending their therapeutic applications far beyond glycemic control in type 2 diabetes (T2D) and obesity. This editorial synthesizes key milestones, from the discovery of GLP-1 to recent clinical trials highlighting the pleiotropic effects of GLP-1RAs in addressing the interconnected spectrum of cardiometabolic conditions, with a focus on cardiovascular, renal, and hepatic benefits. In addition, as GLP-1RAs continue to reshape the management of cardiometabolic disease and global public health, we discuss future challenges to better elucidate their mechanisms of cardiometabolic protection and maximize their therapeutic potential.
KW - Cardiometabolic diseases
KW - Chronic kidney disease
KW - GLP-1
KW - Glucagon-like peptide-1
KW - Metabolic liver disease
KW - Obesity
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85217357343&partnerID=8YFLogxK
U2 - 10.1186/s12933-025-02608-9
DO - 10.1186/s12933-025-02608-9
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C2 - 39881322
AN - SCOPUS:85217357343
SN - 1475-2840
VL - 24
JO - Cardiovascular Diabetology
JF - Cardiovascular Diabetology
IS - 1
M1 - 44
ER -
