@article{c33c86942796494b94eb10bcb54616a8,
title = "Global survival trends for brain tumors, by histology: Analysis of individual records for 67,776 children diagnosed in 61 countries during 2000-2014 (CONCORD-3)",
abstract = "Introduction. Tumors of the central nervous system are among the leading causes of cancer-related death in children. Population-based cancer survival reflects the overall effectiveness of a health care system in managing cancer. Inequity in access to care world-wide may result in survival disparities. Methods. We considered children (0-14 years) diagnosed with a brain tumor during 2000-2014, regardless of tumor behavior. Data underwent a rigorous, three-phase quality control as part of CONCORD-3. We implemented a revised version of the International Classification of Childhood Cancer (third edition) to control for under-registration of non-malignant astrocytic tumors. We estimated net survival using the unbiased nonparametric Pohar Perme estimator. Results. The study included 67,776 children. We estimated survival for 12 histology groups, each based on relevant ICD-O-3 codes. Age-standardized 5-year net survival for low-grade astrocytoma ranged between 84% and 100% world-wide during 2000-2014. In most countries, 5-year survival was 90% or more during 2000-2004, 2005-2009, and 2010-2014. Global variation in survival for medulloblastoma was much wider, with age-standardized 5-year net survival between 47% and 86% for children diagnosed during 2010-2014. Conclusions. To the best of our knowledge, this study provides the largest account to date of global trends in population-based survival for brain tumors in children, by histology. We devised an enhanced version of ICCC-3 to account for differences in cancer registration practices world-wide. Our findings may have public health implications, because low-grade glioma is 1 of the 6 index childhood cancers included by WHO in the Global Initiative for Childhood Cancer.",
keywords = "brain tumor, cancer registries, childhood cancer, international comparisons, survival",
author = "{CONCORD Working Group} and Fabio Girardi and {Di Carlo}, Veronica and Charles Stiller and Gemma Gatta and Woods, {Ryan R.} and Otto Visser and Brigitte Lacour and Tucker, {Thomas C.} and Coleman, {Michel P.} and Claudia Allemani and S. Bouzbid and M. Hamdi-Ch{\'e}rif and L. Kara and K. Meguenni and D. Regagba and S. Bayo and {Cheick Bougadari}, T. and Manraj, {S. S.} and K. Bendahhou and A. Ladipo and Ogunbiyi, {O. J.} and Somdyala, {N. I.M.} and Chaplin, {M. A.} and F. Moreno and Calabrano, {G. H.} and Espinola, {S. B.} and {Carballo Quintero}, B. and R. Fita and Laspada, {W. D.} and Iba{\~n}ez, {S. G.} and Lima, {C. A.} and {Mafra Da Costa}, A. and {De Souza}, {P. C.F.} and J. Chaves and Laporte, {C. A.} and Curado, {M. P.} and {de Oliveira}, {J. C.} and Veneziano, {C. L.A.} and Veneziano, {D. B.} and Almeida, {A. B.M.} and Latorre, {M. R.D.O.} and Rebelo, {M. S.} and Santos, {M. O.} and {Azevedo e Silva}, G. and Galaz, {J. C.} and {Aparicio Aravena}, M. and {Sanhueza Monsalve}, J. and Herrmann, {D. A.} and S. Vargas and Silverman, {B. G.}",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.",
year = "2023",
month = mar,
doi = "10.1093/neuonc/noac232",
language = "אנגלית",
volume = "25",
pages = "593--606",
journal = "Neuro-Oncology",
issn = "1522-8517",
publisher = "Oxford University Press",
number = "3",
}
