Global mortality and readmission rates following COPD exacerbation-related hospitalisation: a meta-analysis of 65 945 individual patients

Kiki Waeijen-Smit; Mieke Crutsen; Spencer Keene; Marc Miravitlles; Ernesto Crisafulli; Antoni Torres; Christian Mueller; Philipp Schuetz; Thomas J. Ringbæk; Fabio Fabbian; Evgeni Mekov; Timothy H. Harries; Chung Tat Lun; Begum Ergan; Cristóbal Esteban; Jose M. Quintana Lopez; José Luis López-Campos; Catherina L. Chang; Robert J. Hancox; Eskandarain Shafuddin; Hollie Ellis; Christer Janson; Charlotte Suppli Ulrik; Gunnar Gudmundsson; Danny Epstein; José Dominguez; Alicia Lacoma; Christian Osadnik; Inmaculada Alia; Francesco Spannella; Zuhal Karakurt; Hossein Mehravaran; Cecile Utens; Martijn D. de Kruif; Fanny Wai San Ko; Samuel P. Trethewey; Alice M. Turner; Dragos Bumbacea; Patrick B. Murphy; Kristina Vermeersch; Shani Zilberman-Itskovich; John Steer; Carlos Echevarria; Stephen C. Bourke; Nicholas Lane; Jordi de Batlle; Roy T.M. Sprooten; Richard Russell; Paola Faverio; Jane L. Cross; Hendrik J. Prins; Martijn A. Spruit; Sami O. Simons; Sarah Houben-Wilke; Frits M.E. Franssen

doi:10.1183/23120541.00838-2023

Global mortality and readmission rates following COPD exacerbation-related hospitalisation: a meta-analysis of 65 945 individual patients

Kiki Waeijen-Smit^*, Mieke Crutsen, Spencer Keene, Marc Miravitlles, Ernesto Crisafulli, Antoni Torres, Christian Mueller, Philipp Schuetz, Thomas J. Ringbæk, Fabio Fabbian, Evgeni Mekov, Timothy H. Harries, Chung Tat Lun, Begum Ergan, Cristóbal Esteban, Jose M. Quintana Lopez, José Luis López-Campos, Catherina L. Chang, Robert J. Hancox, Eskandarain ShafuddinHollie Ellis, Christer Janson, Charlotte Suppli Ulrik, Gunnar Gudmundsson, Danny Epstein, José Dominguez, Alicia Lacoma, Christian Osadnik, Inmaculada Alia, Francesco Spannella, Zuhal Karakurt, Hossein Mehravaran, Cecile Utens, Martijn D. de Kruif, Fanny Wai San Ko, Samuel P. Trethewey, Alice M. Turner, Dragos Bumbacea, Patrick B. Murphy, Kristina Vermeersch, Shani Zilberman-Itskovich, John Steer, Carlos Echevarria, Stephen C. Bourke, Nicholas Lane, Jordi de Batlle, Roy T.M. Sprooten, Richard Russell, Paola Faverio, Jane L. Cross, Hendrik J. Prins, Martijn A. Spruit, Sami O. Simons, Sarah Houben-Wilke, Frits M.E. Franssen

^*Corresponding author for this work

Internal Medicine

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Abstract

Background Exacerbations of COPD (ECOPD) have a major impact on patients and healthcare systems across the world. Precise estimates of the global burden of ECOPD on mortality and hospital readmission are needed to inform policy makers and aid preventive strategies to mitigate this burden. The aims of the present study were to explore global in-hospital mortality, post-discharge mortality and hospital readmission rates after ECOPD-related hospitalisation using an individual patient data meta-analysis (IPDMA) design. Methods A systematic review was performed identifying studies that reported in-hospital mortality, postdischarge mortality and hospital readmission rates following ECOPD-related hospitalisation. Data analyses were conducted using a one-stage random-effects meta-analysis model. This study was conducted and reported in accordance with the PRISMA-IPD statement. Results Data of 65 945 individual patients with COPD were analysed. The pooled in-hospital mortality rate was 6.2%, pooled 30-, 90- and 365-day post-discharge mortality rates were 1.8%, 5.5% and 10.9%, respectively, and pooled 30-, 90- and 365-day hospital readmission rates were 7.1%, 12.6% and 32.1%, respectively, with noticeable variability between studies and countries.

Original language	English
Article number	00838-2023
Journal	ERJ Open Research
Volume	10
Issue number	1
DOIs	https://doi.org/10.1183/23120541.00838-2023
State	Published - 2024

Funding

Funders	Funder number
ZonMWAQ10	90030355

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10.1183/23120541.00838-2023

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Waeijen-Smit, K., Crutsen, M., Keene, S., Miravitlles, M., Crisafulli, E., Torres, A., Mueller, C., Schuetz, P., Ringbæk, T. J., Fabbian, F., Mekov, E., Harries, T. H., Lun, C. T., Ergan, B., Esteban, C., Quintana Lopez, J. M., López-Campos, J. L., Chang, C. L., Hancox, R. J., ... Franssen, F. M. E. (2024). Global mortality and readmission rates following COPD exacerbation-related hospitalisation: a meta-analysis of 65 945 individual patients. ERJ Open Research, 10(1), Article 00838-2023. https://doi.org/10.1183/23120541.00838-2023

@article{ab1888a458db488faffebfc4d1443b6f,

title = "Global mortality and readmission rates following COPD exacerbation-related hospitalisation: a meta-analysis of 65 945 individual patients",

abstract = "Background Exacerbations of COPD (ECOPD) have a major impact on patients and healthcare systems across the world. Precise estimates of the global burden of ECOPD on mortality and hospital readmission are needed to inform policy makers and aid preventive strategies to mitigate this burden. The aims of the present study were to explore global in-hospital mortality, post-discharge mortality and hospital readmission rates after ECOPD-related hospitalisation using an individual patient data meta-analysis (IPDMA) design. Methods A systematic review was performed identifying studies that reported in-hospital mortality, postdischarge mortality and hospital readmission rates following ECOPD-related hospitalisation. Data analyses were conducted using a one-stage random-effects meta-analysis model. This study was conducted and reported in accordance with the PRISMA-IPD statement. Results Data of 65 945 individual patients with COPD were analysed. The pooled in-hospital mortality rate was 6.2%, pooled 30-, 90- and 365-day post-discharge mortality rates were 1.8%, 5.5% and 10.9%, respectively, and pooled 30-, 90- and 365-day hospital readmission rates were 7.1%, 12.6% and 32.1%, respectively, with noticeable variability between studies and countries.",

author = "Kiki Waeijen-Smit and Mieke Crutsen and Spencer Keene and Marc Miravitlles and Ernesto Crisafulli and Antoni Torres and Christian Mueller and Philipp Schuetz and Ringb{\ae}k, {Thomas J.} and Fabio Fabbian and Evgeni Mekov and Harries, {Timothy H.} and Lun, {Chung Tat} and Begum Ergan and Crist{\'o}bal Esteban and {Quintana Lopez}, {Jose M.} and L{\'o}pez-Campos, {Jos{\'e} Luis} and Chang, {Catherina L.} and Hancox, {Robert J.} and Eskandarain Shafuddin and Hollie Ellis and Christer Janson and Ulrik, {Charlotte Suppli} and Gunnar Gudmundsson and Danny Epstein and Jos{\'e} Dominguez and Alicia Lacoma and Christian Osadnik and Inmaculada Alia and Francesco Spannella and Zuhal Karakurt and Hossein Mehravaran and Cecile Utens and {de Kruif}, {Martijn D.} and {San Ko}, {Fanny Wai} and Trethewey, {Samuel P.} and Turner, {Alice M.} and Dragos Bumbacea and Murphy, {Patrick B.} and Kristina Vermeersch and Shani Zilberman-Itskovich and John Steer and Carlos Echevarria and Bourke, {Stephen C.} and Nicholas Lane and {de Batlle}, Jordi and Sprooten, {Roy T.M.} and Richard Russell and Paola Faverio and Cross, {Jane L.} and Prins, {Hendrik J.} and Spruit, {Martijn A.} and Simons, {Sami O.} and Sarah Houben-Wilke and Franssen, {Frits M.E.}",

year = "2024",

doi = "10.1183/23120541.00838-2023",

language = "אנגלית",

volume = "10",

journal = "ERJ Open Research",

issn = "2312-0541",

publisher = "European Respiratory Society",

number = "1",

}

Waeijen-Smit, K, Crutsen, M, Keene, S, Miravitlles, M, Crisafulli, E, Torres, A, Mueller, C, Schuetz, P, Ringbæk, TJ, Fabbian, F, Mekov, E, Harries, TH, Lun, CT, Ergan, B, Esteban, C, Quintana Lopez, JM, López-Campos, JL, Chang, CL, Hancox, RJ, Shafuddin, E, Ellis, H, Janson, C, Ulrik, CS, Gudmundsson, G, Epstein, D, Dominguez, J, Lacoma, A, Osadnik, C, Alia, I, Spannella, F, Karakurt, Z, Mehravaran, H, Utens, C, de Kruif, MD, San Ko, FW, Trethewey, SP, Turner, AM, Bumbacea, D, Murphy, PB, Vermeersch, K, Zilberman-Itskovich, S, Steer, J, Echevarria, C, Bourke, SC, Lane, N, de Batlle, J, Sprooten, RTM, Russell, R, Faverio, P, Cross, JL, Prins, HJ, Spruit, MA, Simons, SO, Houben-Wilke, S & Franssen, FME 2024, 'Global mortality and readmission rates following COPD exacerbation-related hospitalisation: a meta-analysis of 65 945 individual patients', ERJ Open Research, vol. 10, no. 1, 00838-2023. https://doi.org/10.1183/23120541.00838-2023

TY - JOUR

T1 - Global mortality and readmission rates following COPD exacerbation-related hospitalisation

T2 - a meta-analysis of 65 945 individual patients

AU - Waeijen-Smit, Kiki

AU - Crutsen, Mieke

AU - Keene, Spencer

AU - Miravitlles, Marc

AU - Crisafulli, Ernesto

AU - Torres, Antoni

AU - Mueller, Christian

AU - Schuetz, Philipp

AU - Ringbæk, Thomas J.

AU - Fabbian, Fabio

AU - Mekov, Evgeni

AU - Harries, Timothy H.

AU - Lun, Chung Tat

AU - Ergan, Begum

AU - Esteban, Cristóbal

AU - Quintana Lopez, Jose M.

AU - López-Campos, José Luis

AU - Chang, Catherina L.

AU - Hancox, Robert J.

AU - Shafuddin, Eskandarain

AU - Ellis, Hollie

AU - Janson, Christer

AU - Ulrik, Charlotte Suppli

AU - Gudmundsson, Gunnar

AU - Epstein, Danny

AU - Dominguez, José

AU - Lacoma, Alicia

AU - Osadnik, Christian

AU - Alia, Inmaculada

AU - Spannella, Francesco

AU - Karakurt, Zuhal

AU - Mehravaran, Hossein

AU - Utens, Cecile

AU - de Kruif, Martijn D.

AU - San Ko, Fanny Wai

AU - Trethewey, Samuel P.

AU - Turner, Alice M.

AU - Bumbacea, Dragos

AU - Murphy, Patrick B.

AU - Vermeersch, Kristina

AU - Zilberman-Itskovich, Shani

AU - Steer, John

AU - Echevarria, Carlos

AU - Bourke, Stephen C.

AU - Lane, Nicholas

AU - de Batlle, Jordi

AU - Sprooten, Roy T.M.

AU - Russell, Richard

AU - Faverio, Paola

AU - Cross, Jane L.

AU - Prins, Hendrik J.

AU - Spruit, Martijn A.

AU - Simons, Sami O.

AU - Houben-Wilke, Sarah

AU - Franssen, Frits M.E.

PY - 2024

Y1 - 2024

N2 - Background Exacerbations of COPD (ECOPD) have a major impact on patients and healthcare systems across the world. Precise estimates of the global burden of ECOPD on mortality and hospital readmission are needed to inform policy makers and aid preventive strategies to mitigate this burden. The aims of the present study were to explore global in-hospital mortality, post-discharge mortality and hospital readmission rates after ECOPD-related hospitalisation using an individual patient data meta-analysis (IPDMA) design. Methods A systematic review was performed identifying studies that reported in-hospital mortality, postdischarge mortality and hospital readmission rates following ECOPD-related hospitalisation. Data analyses were conducted using a one-stage random-effects meta-analysis model. This study was conducted and reported in accordance with the PRISMA-IPD statement. Results Data of 65 945 individual patients with COPD were analysed. The pooled in-hospital mortality rate was 6.2%, pooled 30-, 90- and 365-day post-discharge mortality rates were 1.8%, 5.5% and 10.9%, respectively, and pooled 30-, 90- and 365-day hospital readmission rates were 7.1%, 12.6% and 32.1%, respectively, with noticeable variability between studies and countries.

AB - Background Exacerbations of COPD (ECOPD) have a major impact on patients and healthcare systems across the world. Precise estimates of the global burden of ECOPD on mortality and hospital readmission are needed to inform policy makers and aid preventive strategies to mitigate this burden. The aims of the present study were to explore global in-hospital mortality, post-discharge mortality and hospital readmission rates after ECOPD-related hospitalisation using an individual patient data meta-analysis (IPDMA) design. Methods A systematic review was performed identifying studies that reported in-hospital mortality, postdischarge mortality and hospital readmission rates following ECOPD-related hospitalisation. Data analyses were conducted using a one-stage random-effects meta-analysis model. This study was conducted and reported in accordance with the PRISMA-IPD statement. Results Data of 65 945 individual patients with COPD were analysed. The pooled in-hospital mortality rate was 6.2%, pooled 30-, 90- and 365-day post-discharge mortality rates were 1.8%, 5.5% and 10.9%, respectively, and pooled 30-, 90- and 365-day hospital readmission rates were 7.1%, 12.6% and 32.1%, respectively, with noticeable variability between studies and countries.

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U2 - 10.1183/23120541.00838-2023

DO - 10.1183/23120541.00838-2023

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C2 - 38410700

AN - SCOPUS:85188618068

SN - 2312-0541

VL - 10

JO - ERJ Open Research

JF - ERJ Open Research

IS - 1

M1 - 00838-2023

ER -

Global mortality and readmission rates following COPD exacerbation-related hospitalisation: a meta-analysis of 65 945 individual patients

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