@article{b0882e1d9aa04746991a7ccc71d75637,
title = "Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study",
abstract = "Background Antibiotic resistance is a major global health problem and pathogens such as meticillin-resistant Staphylococcus aureus (MRSA) have become of particular concern in the management of lower respiratory tract infections. However, few data are available on the worldwide prevalence and risk factors for MRSA pneumonia. We aimed to determine the point prevalence of MRSA pneumonia and identify specific MRSA risk factors in community-dwelling patients hospitalised with pneumonia. Methods We did an international, multicentre study of community-dwelling, adult patients admitted to hospital with pneumonia who had microbiological tests taken within 24 h of presentation. We recruited investigators from 222 hospitals in 54 countries to gather point-prevalence data for all patients admitted with these characteristics during 4 days randomly selected during the months of March, April, May, and June in 2015. We assessed prevalence of MRSA pneumonia and associated risk factors through logistic regression analysis. Findings 3702 patients hospitalised with pneumonia were enrolled, with 3193 patients receiving microbiological tests within 24 h of admission, forming the patient population. 1173 (37%) had at least one pathogen isolated (culture-positive population). The overall prevalence of confirmed MRSA pneumonia was 3·0% (n=95), with differing prevalence between continents and countries. Three risk factors were independently associated with MRSA pneumonia: previous MRSA infection or colonisation (odds ratio 6·21, 95% CI 3·25–11·85), recurrent skin infections (2·87, 1·10–7·45), and severe pneumonia disease (2·39, 1·55–3·68). Interpretation This multicountry study shows low prevalence of MRSA pneumonia and specific MRSA risk factors among community-dwelling patients hospitalised with pneumonia. Funding None.",
author = "{GLIMP investigators} and Stefano Aliberti and Reyes, {Luis F.} and Paola Faverio and Giovanni Sotgiu and Simone Dore and Rodriguez, {Alejandro H.} and Soni, {Nilam J.} and Restrepo, {Marcos I.} and Aruj, {P. K.} and S. Attorri and E. Barimboim and Caeiro, {J. P.} and Garz{\'o}n, {M. I.} and VH Cambursano and A. Ceccato and J. Chertcoff and F. Lascar and {Di Tulio}, F. and {Cordon D{\'i}az}, A. and {de Vedia}, L. and Ganaha, {M. C.} and S. Lambert and G. Lopardo and Luna, {C. M.} and Malberti, {A. G.} and N. Morcillo and S. Tartara and C. Pensotti and B. Pereyra and Scapellato, {P. G.} and Stagnaro, {J. P.} and S. Shah and F. L{\"o}tsch and F. Thalhammer and Vincent, {J. L.} and K. Anseeuw and Francois, {C. A.} and {Van Braeckel}, E. and Djimon, {M. Z.} and J. Bashi and R. Dodo and {Aranha Nou{\'e}r}, S. and P. Chipev and M. Encheva and D. Miteva and D. Petkova and Balkissou, {A. D.} and {Pefura Yone}, {E. W.} and {Mbatchou Ngahane}, {B. H.} and Y. Maor",
note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",
year = "2016",
month = dec,
day = "1",
doi = "10.1016/S1473-3099(16)30267-5",
language = "אנגלית",
volume = "16",
pages = "1364--1376",
journal = "The Lancet Infectious Diseases",
issn = "1473-3099",
publisher = "Elsevier Ltd.",
number = "12",
}