@article{5c2a4b28dfab4eb9a84a7d78a9f82ae2,
title = "Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland",
abstract = "Photoreceptors in the vertebrate eye are dependent on the retinal pigmented epithelium for a variety of functions including retinal re-isomerization and waste disposal. The light-sensitive pineal gland of fish, birds, and amphibians is evolutionarily related to the eye but lacks a pigmented epithelium. Thus, it is unclear how these functions are performed. Here, we ask whether a subpopulation of zebrafish pineal cells, which express glial markers and visual cycle genes, is involved in maintaining photoreceptors. Selective ablation of these cells leads to a loss of pineal photoreceptors. Moreover, these cells internalize exorhodopsin that is secreted by pineal rod-like photoreceptors, and in turn release CD63-positive extracellular vesicles (EVs) that are taken up by pdgfrb-positive phagocytic cells in the forebrain meninges. These results identify a subpopulation of glial cells that is critical for pineal photoreceptor survival and indicate the existence of cells in the forebrain meninges that receive EVs released by these pineal cells and potentially function in waste disposal.",
keywords = "clearance, extracellular vesicles, glia, meninges, rhodopsin, visual cycle",
author = "Yotam Elazary and Kathleen Cheow and Cheng, {Ruey Kuang} and Raghumoy Ghosh and Inbal Shainer and Yair Wexler and Karen Crasta and Yoav Gothilf and Jesuthasan, {Suresh J.}",
note = "Publisher Copyright: {\textcopyright} 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2023",
month = apr,
doi = "10.1111/jpi.12854",
language = "אנגלית",
volume = "74",
journal = "Journal of Pineal Research",
issn = "0742-3098",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "3",
}