TY - JOUR
T1 - Glassy Dynamics and Memory Effects in an Intrinsically Disordered Protein Construct
AU - Morgan, Ian L.
AU - Avinery, Ram
AU - Rahamim, Gil
AU - Beck, Roy
AU - Saleh, Omar A.
N1 - Publisher Copyright:
© 2020 American Physical Society.
PY - 2020/7/31
Y1 - 2020/7/31
N2 - Glassy, nonexponential relaxations in globular proteins are typically attributed to conformational behaviors that are missing from intrinsically disordered proteins. Yet, we show that single molecules of a disordered-protein construct display two signatures of glassy dynamics, logarithmic relaxations and a Kovacs memory effect, in response to changes in applied tension. We attribute this to the presence of multiple independent local structures in the chain, which we corroborate with a model that correctly predicts the force dependence of the relaxation. The mechanism established here likely applies to other disordered proteins.
AB - Glassy, nonexponential relaxations in globular proteins are typically attributed to conformational behaviors that are missing from intrinsically disordered proteins. Yet, we show that single molecules of a disordered-protein construct display two signatures of glassy dynamics, logarithmic relaxations and a Kovacs memory effect, in response to changes in applied tension. We attribute this to the presence of multiple independent local structures in the chain, which we corroborate with a model that correctly predicts the force dependence of the relaxation. The mechanism established here likely applies to other disordered proteins.
UR - http://www.scopus.com/inward/record.url?scp=85089514049&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.125.058001
DO - 10.1103/PhysRevLett.125.058001
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C2 - 32794838
AN - SCOPUS:85089514049
SN - 0031-9007
VL - 125
JO - Physical Review Letters
JF - Physical Review Letters
IS - 5
M1 - 058001
ER -