Geometry of Gene Expression Space of Wilms’ Tumors From Human Patients

Ariel Trink, Itamar Kanter, Naomi Pode-Shakked, Achia Urbach, Benjamin Dekel, Tomer Kalisky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Wilms’ tumor is a pediatric malignancy that is thought to originate from faulty kidney development during the embryonic stage. However, there is a large variation between tumors from different patients in both histology and gene expression that is not well characterized. Here we use a meta-analysis of published microarray datasets to show that Favorable Histology Wilms’ Tumors (FHWT's) fill a triangle-shaped continuum in gene expression space of which the vertices represent three idealized “archetypes”. We show that these archetypes have predominantly renal blastemal, stromal, and epithelial characteristics and that they correlate well with the three major lineages of the developing embryonic kidney. Moreover, we show that advanced stage tumors shift towards the renal blastemal archetype. These results illustrate the potential of this methodology for characterizing the cellular composition of Wilms’ tumors and for assessing disease progression.

Original languageEnglish
Pages (from-to)871-881
Number of pages11
JournalNeoplasia (United States)
Volume20
Issue number8
DOIs
StatePublished - Aug 2018

Funding

FundersFunder number
EU-FP7
Seventh Framework Programme618592
Israel Cancer Association20150911
Israel Science Foundation2017/13, 1634/13, 1902/12
Ministry of Health, State of Israel3–10146

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