Genomic organization of the ATM gene

Tamar Uziel, Kinneret Savitsky, Matthias Platzer, Yael Ziv, Tal Helbitz, Michael Nehls, Thomas Boehm, Andre Rosenthal, Yosef Shiloh, Galit Rotman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The ATM gene was recently identified and found to be responsible for the human genetic disorder ataxia-telangiectasia. The major ATM transcript is 13 kb. Using long-distance PCR, we determined the genomic structure of this gene and identified all of its exon-intron boundaries. The ATM gene spans approximately 150 kb of genomic DNA and consists of 66 exons. The initiation codon falls within exon 4. The last exon is 3.8 kb and contains the stop codon and a 3'-untranslated region of about 3600 nucleotides.

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalGenomics
Volume33
Issue number2
DOIs
StatePublished - 15 Apr 1996

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