TY - JOUR
T1 - Genomic evolution of cancer models
T2 - perils and opportunities
AU - Ben-David, Uri
AU - Beroukhim, Rameen
AU - Golub, Todd R.
N1 - Publisher Copyright:
© 2018, Springer Nature Limited.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Cancer research relies on model systems, which reflect the biology of actual human tumours to only a certain extent. One important feature of human cancer is its intra-tumour genomic heterogeneity and instability. However, the extent of such genomic instability in cancer models has received limited attention in research. Here, we review the state of knowledge of genomic instability of cancer models and discuss its biological origins and implications for basic research and for cancer precision medicine. We discuss strategies to cope with such genomic evolution and evaluate both the perils and the emerging opportunities associated with it.
AB - Cancer research relies on model systems, which reflect the biology of actual human tumours to only a certain extent. One important feature of human cancer is its intra-tumour genomic heterogeneity and instability. However, the extent of such genomic instability in cancer models has received limited attention in research. Here, we review the state of knowledge of genomic instability of cancer models and discuss its biological origins and implications for basic research and for cancer precision medicine. We discuss strategies to cope with such genomic evolution and evaluate both the perils and the emerging opportunities associated with it.
UR - http://www.scopus.com/inward/record.url?scp=85058993294&partnerID=8YFLogxK
U2 - 10.1038/s41568-018-0095-3
DO - 10.1038/s41568-018-0095-3
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AN - SCOPUS:85058993294
VL - 19
SP - 97
EP - 109
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
IS - 2
ER -
