TY - JOUR
T1 - Genomic analyses of primary and metastatic serous epithelial ovarian cancer
AU - Israeli, Ofir
AU - Gotlieb, Walter H.
AU - Friedman, Eitan
AU - Korach, Jacob
AU - Friedman, Eddy
AU - Goldman, Boleslaw
AU - Zeltser, Assaf
AU - Ben-Baruch, Gilad
AU - Rienstein, Shlomit
AU - Aviram-Goldring, Ayala
N1 - Funding Information:
This study was supported in part by the GIF (German-Israeli Foundation Research and Development) grant (No. G-491-112). This work was performed in partial fulfillment of the requirements for Ph.D. degree of Ofir Israeli, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
PY - 2004/10/1
Y1 - 2004/10/1
N2 - Epithelial ovarian cancer is the most lethal gynecologic malignancy in the western world. In 75% of patients, peritoneal metastases are found at the time of primary surgery. However, the genetic events leading to the development of ovarian tumors and to the genetic progression toward metastasis remain unclear. To gain insight into this issue, the types and patterns of DNA copy number changes were compared between primary ovarian tumors and their respective metastases by using comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH). The genetic alterations (deletions and amplifications) detected by CGH were similar in the primary tumors and in their respective metastases. Moreover, the FISH results show a similar pattern of chromosomal abnormalities. Our results imply that the major gross genetic changes in ovarian cancer take place in the primary tumor, and the additional genetic changes that may occur in the metastases are not detectable by CGH.
AB - Epithelial ovarian cancer is the most lethal gynecologic malignancy in the western world. In 75% of patients, peritoneal metastases are found at the time of primary surgery. However, the genetic events leading to the development of ovarian tumors and to the genetic progression toward metastasis remain unclear. To gain insight into this issue, the types and patterns of DNA copy number changes were compared between primary ovarian tumors and their respective metastases by using comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH). The genetic alterations (deletions and amplifications) detected by CGH were similar in the primary tumors and in their respective metastases. Moreover, the FISH results show a similar pattern of chromosomal abnormalities. Our results imply that the major gross genetic changes in ovarian cancer take place in the primary tumor, and the additional genetic changes that may occur in the metastases are not detectable by CGH.
UR - http://www.scopus.com/inward/record.url?scp=4644269690&partnerID=8YFLogxK
U2 - 10.1016/j.cancergencyto.2004.02.006
DO - 10.1016/j.cancergencyto.2004.02.006
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AN - SCOPUS:4644269690
SN - 0165-4608
VL - 154
SP - 16
EP - 21
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -
