Genomic analyses of primary and metastatic serous epithelial ovarian cancer

Ofir Israeli, Walter H. Gotlieb, Eitan Friedman, Jacob Korach, Eddy Friedman, Boleslaw Goldman, Assaf Zeltser, Gilad Ben-Baruch, Shlomit Rienstein, Ayala Aviram-Goldring

Research output: Contribution to journalArticlepeer-review

Abstract

Epithelial ovarian cancer is the most lethal gynecologic malignancy in the western world. In 75% of patients, peritoneal metastases are found at the time of primary surgery. However, the genetic events leading to the development of ovarian tumors and to the genetic progression toward metastasis remain unclear. To gain insight into this issue, the types and patterns of DNA copy number changes were compared between primary ovarian tumors and their respective metastases by using comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH). The genetic alterations (deletions and amplifications) detected by CGH were similar in the primary tumors and in their respective metastases. Moreover, the FISH results show a similar pattern of chromosomal abnormalities. Our results imply that the major gross genetic changes in ovarian cancer take place in the primary tumor, and the additional genetic changes that may occur in the metastases are not detectable by CGH.

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume154
Issue number1
DOIs
StatePublished - 1 Oct 2004
Externally publishedYes

Funding

FundersFunder number
German-Israeli Foundation Research and DevelopmentG-491-112

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