TY - JOUR
T1 - Genome-wide profiling of Laron syndrome patients identifies novel cancer protection pathways
AU - Werner, Haim
AU - Lapkina-Gendler, Lena
AU - Achlaug, Laris
AU - Nagaraj, Karthik
AU - Somri, Lina
AU - Yaron-Saminsky, Danielle
AU - Pasmanik-Chor, Metsada
AU - Sarfstein, Rive
AU - Laron, Zvi
AU - Yakar, Shoshana
N1 - Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019
Y1 - 2019
N2 - Laron syndrome (LS), or primary growth hormone resistance, is a prototypical congenital insulin-like growth factor 1 (IGF1) deficiency. The recent epidemiological finding that LS patients do not develop cancer is of major scientific and clinical relevance. Epidemiological data suggest that congenital IGF1 deficiency confers protection against the development of malignancies. This ‘experiment of nature’ reflects the critical role of IGF1 in tumor biology. The present review article provides an overview of recently conducted genome-wide profiling analyses aimed at identifying mechanisms and signaling pathways that are directly responsible for the link between life-time low IGF1 levels and protection from tumor development. The review underscores the concept that ‘data mining’ an orphan disease might translate into new developments in oncology.
AB - Laron syndrome (LS), or primary growth hormone resistance, is a prototypical congenital insulin-like growth factor 1 (IGF1) deficiency. The recent epidemiological finding that LS patients do not develop cancer is of major scientific and clinical relevance. Epidemiological data suggest that congenital IGF1 deficiency confers protection against the development of malignancies. This ‘experiment of nature’ reflects the critical role of IGF1 in tumor biology. The present review article provides an overview of recently conducted genome-wide profiling analyses aimed at identifying mechanisms and signaling pathways that are directly responsible for the link between life-time low IGF1 levels and protection from tumor development. The review underscores the concept that ‘data mining’ an orphan disease might translate into new developments in oncology.
KW - Cancer protection
KW - Growth hormone receptor (GH-R)
KW - IGF1 receptor (IGF1R)
KW - Insulin-like growth factor 1 (IGF1)
KW - Laron syndrome
KW - Thioredoxin-interacting protein (TXNIP)
UR - http://www.scopus.com/inward/record.url?scp=85079877135&partnerID=8YFLogxK
U2 - 10.3390/cells8060596
DO - 10.3390/cells8060596
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AN - SCOPUS:85079877135
SN - 2073-4409
VL - 8
JO - Cells
JF - Cells
IS - 6
M1 - 596
ER -
