TY - JOUR
T1 - Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
AU - AMFS Investigators
AU - ATHENS Melanoma Study Group
AU - GenoMEL Consortium
AU - Essen-Heidelberg Investigators
AU - The SDH Study Group
AU - Q-MEGA and QTWIN Investigators
AU - Law, Matthew H.
AU - Bishop, D. Timothy
AU - Lee, Jeffrey E.
AU - Brossard, Myriam
AU - Martin, Nicholas G.
AU - Moses, Eric K.
AU - Song, Fengju
AU - Barrett, Jennifer H.
AU - Kumar, Rajiv
AU - Easton, Douglas F.
AU - Pharoah, Paul D.P.
AU - Swerdlow, Anthony J.
AU - Kypreou, Katerina P.
AU - Taylor, John C.
AU - Harland, Mark
AU - Randerson-Moor, Juliette
AU - Akslen, Lars A.
AU - Andresen, Per A.
AU - Avril, Marie Françoise
AU - Azizi, Esther
AU - Scarrà, Giovanna Bianchi
AU - Brown, Kevin M.
AU - Dębniak, Tadeusz
AU - Duffy, David L.
AU - Elder, David E.
AU - Fang, Shenying
AU - Friedman, Eitan
AU - Galan, Pilar
AU - Ghiorzo, Paola
AU - Gillanders, Elizabeth M.
AU - Goldstein, Alisa M.
AU - Gruis, Nelleke A.
AU - Hansson, Johan
AU - Helsing, Per
AU - Hočevar, Marko
AU - Höiom, Veronica
AU - Ingvar, Christian
AU - Kanetsky, Peter A.
AU - Chen, Wei V.
AU - Landi, Maria Teresa
AU - Lang, Julie
AU - Lathrop, G. Mark
AU - Lubiński, Jan
AU - MacKie, Rona M.
AU - Mann, Graham J.
AU - Molven, Anders
AU - Montgomery, Grant W.
AU - Novaković, Srdjan
AU - Olsson, Håkan
AU - Puig, Susana
N1 - Publisher Copyright:
© 2015 Nature America, Inc. All rights reserved.
PY - 2015/8/27
Y1 - 2015/8/27
N2 - Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10-8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.
AB - Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10-8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.
UR - http://www.scopus.com/inward/record.url?scp=84940734774&partnerID=8YFLogxK
U2 - 10.1038/ng.3373
DO - 10.1038/ng.3373
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AN - SCOPUS:84940734774
SN - 1061-4036
VL - 47
SP - 987
EP - 995
JO - Nature Genetics
JF - Nature Genetics
IS - 9
ER -
