Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

Nick Orr, Alina Lemnrau, Rosie Cooke, Olivia Fletcher, Katarzyna Tomczyk, Michael Jones, Nichola Johnson, Christopher J. Lord, Costas Mitsopoulos, Marketa Zvelebil, Simon S. McDade, Gemma Buck, Christine Blancher, Alison H. Trainer, Paul A. James, Stig E. Bojesen, Susanne Bokmand, Heli Nevanlinna, Johanna Mattson, Eitan FriedmanYael Laitman, Domenico Palli, Giovanna Masala, Ines Zanna, Laura Ottini, Giuseppe Giannini, Antoinette Hollestelle, Ans M.W. Van Den Ouweland, Srdjan Novaković, Mateja Krajc, Manuela Gago-Dominguez, Jose Esteban Castelao, Håkan Olsson, Ingrid Hedenfalk, Douglas F. Easton, Paul D.P. Pharoah, Alison M. Dunning, D. Timothy Bishop, Susan L. Neuhausen, Linda Steele, Richard S. Houlston, Montserrat Garcia-Closas, Alan Ashworth, Anthony J. Swerdlow

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10-13; odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10-15; OR = 1.50).

Original languageEnglish
Pages (from-to)1182-1184
Number of pages3
JournalNature Genetics
Volume44
Issue number11
DOIs
StatePublished - Nov 2012

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