Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss

Estonian Biobank Research Team

Research output: Contribution to journalArticlepeer-review

Abstract

Hearing loss is one of the top contributors to years lived with disability and is a risk factor for dementia. Molecular evidence on the cellular origins of hearing loss in humans is growing. Here, we performed a genome-wide association meta-analysis of clinically diagnosed and self-reported hearing impairment on 723,266 individuals and identified 48 significant loci, 10 of which are novel. A large proportion of associations comprised missense variants, half of which lie within known familial hearing loss loci. We used single-cell RNA-sequencing data from mouse cochlea and brain and mapped common-variant genomic results to spindle, root, and basal cells from the stria vascularis, a structure in the cochlea necessary for normal hearing. Our findings indicate the importance of the stria vascularis in the mechanism of hearing impairment, providing future paths for developing targets for therapeutic intervention in hearing loss.

Original languageEnglish
Pages (from-to)1077-1091
Number of pages15
JournalAmerican Journal of Human Genetics
Volume109
Issue number6
DOIs
StatePublished - 2 Jun 2022

Keywords

  • ARHL
  • basal cells
  • cochlea
  • genetics
  • GWAS
  • hair cells
  • hearing loss
  • root cells
  • spindle cells
  • stria vascularis

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