Genome Sequence of an Emerging Salmonella enterica Serovar Infantis and Genomic Comparison with Other S. Infantis Strains

Emiliano Cohen, Galia Rahav, Ohad Gal-Mor, Howard Ochman

Research output: Contribution to journalArticlepeer-review

Abstract

Salmonella enterica serovar Infantis (S. Infantis) is one of the dominant serovars of the bacterial pathogen S. enterica. In recent years, the number of human infections caused by S. Infantis has been increasing in many countries, and often the emerging population harbors a unique virulence-resistant megaplasmid called plasmid of emerging S. Infantis (pESI). Here, we report the complete gap-free genome sequence of the S. Infantis Israeli emerging clone and compare its chromosome and pESI sequences with other complete S. Infantis genomes. We show a conserved presence of the Salmonella pathogenicity islands 1-6, 9, 11, 12, and CS54 and a common integration of five bacteriophages in the S. Infantis chromosome. In contrast, we found variable presence of additionally three chromosomally integrated phages and eight modular regions in pESI, which contribute to the genetic and phenotypic diversity (including antimicrobial resistance) of this ubiquitous foodborne pathogen.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalGenome Biology and Evolution
Volume12
Issue number3
DOIs
StatePublished - 17 Mar 2020

Keywords

  • HGT
  • Salmonella Infantis
  • WGS
  • mobile genetic elements
  • pESI
  • virulence

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