Genome-scale modeling of tissue and cancer metabolism

Livnat Jerby, Eytan Ruppin*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The emergence of ‘omics’ technologies has enabled global reconstruction of cellular metabolic networks. While detailed kinetic modeling of these networks remain challenging due to a lack of kinetic, network analysis based on appropriate constraints such as the steady-state condition (constraint-based analysis) is already feasible. Here the methods for the reconstruction of metabolic networks are reviewed along with recent developments in the field, including the modeling techniques such as flux balance analysis and elementary flux modes.

Original languageEnglish
Title of host publicationA Systems Biology Approach to Study Metabolic Syndrome
PublisherSpringer International Publishing
Number of pages18
ISBN (Electronic)9783319010083
ISBN (Print)9783319010076
StatePublished - 1 Jan 2014


  • Constraint based modeling
  • Human metabolic model
  • Metabolic networks


Dive into the research topics of 'Genome-scale modeling of tissue and cancer metabolism'. Together they form a unique fingerprint.

Cite this