The emergence of ‘omics’ technologies has enabled global reconstruction of cellular metabolic networks. While detailed kinetic modeling of these networks remain challenging due to a lack of kinetic, network analysis based on appropriate constraints such as the steady-state condition (constraint-based analysis) is already feasible. Here the methods for the reconstruction of metabolic networks are reviewed along with recent developments in the field, including the modeling techniques such as flux balance analysis and elementary flux modes.
|Title of host publication||A Systems Biology Approach to Study Metabolic Syndrome|
|Publisher||Springer International Publishing|
|Number of pages||18|
|State||Published - 1 Jan 2014|
- Constraint based modeling
- Human metabolic model
- Metabolic networks