Genetics of sudden cardiac death

Alon Barsheshet*, Andrew Brenyo, Arthur J. Moss, Ilan Goldenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Advances in genetic testing technology have led to a proliferation of new genetic tests and accelerated developments in the field of cardiovascular genetic medicine. These advances enhance presymptomatic diagnosis and can establish a definitive molecular diagnosis for symptomatic patients at risk for sudden cardiac death. Most importantly, genotype-phenotype correlations can add important information for predicting outcome and selecting treatment for patients with inherited arrhythmic disorders. This paper reviews the current data regarding genotype-phenotype correlations and the role of clinical genetic testing in diagnosis, prognosis, and management of inheritable disorders leading to sudden cardiac death.

Original languageEnglish
Pages (from-to)364-376
Number of pages13
JournalCurrent Cardiology Reports
Volume13
Issue number5
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • ARVC/D
  • Aborted cardiac arrest
  • Arrhythmia
  • Brugada syndrome
  • CPVT
  • Catecholaminergic polymorphic ventricular tachycardia
  • Diagnosis
  • Dilated cardiomyopathy
  • Genes
  • Genetic testing
  • Genetics
  • Hypertrophic cardiomyopathy
  • LQTS
  • Long QT syndrome
  • Prognosis
  • Risk assessment
  • SCD
  • Short QT syndrome
  • Sudden cardiac death

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