Abstract
Advances in genetic testing technology have led to a proliferation of new genetic tests and accelerated developments in the field of cardiovascular genetic medicine. These advances enhance presymptomatic diagnosis and can establish a definitive molecular diagnosis for symptomatic patients at risk for sudden cardiac death. Most importantly, genotype-phenotype correlations can add important information for predicting outcome and selecting treatment for patients with inherited arrhythmic disorders. This paper reviews the current data regarding genotype-phenotype correlations and the role of clinical genetic testing in diagnosis, prognosis, and management of inheritable disorders leading to sudden cardiac death.
Original language | English |
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Pages (from-to) | 364-376 |
Number of pages | 13 |
Journal | Current Cardiology Reports |
Volume | 13 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2011 |
Externally published | Yes |
Keywords
- ARVC/D
- Aborted cardiac arrest
- Arrhythmia
- Brugada syndrome
- CPVT
- Catecholaminergic polymorphic ventricular tachycardia
- Diagnosis
- Dilated cardiomyopathy
- Genes
- Genetic testing
- Genetics
- Hypertrophic cardiomyopathy
- LQTS
- Long QT syndrome
- Prognosis
- Risk assessment
- SCD
- Short QT syndrome
- Sudden cardiac death