@article{2f8dc72ba04e4df19bf88a9d89e2f259,
title = "Genetics of inflammatory bowel disease",
abstract = "The etiology of inflammatory bowel diseases, Crohn's disease and ulcerative colitis, is uncertain. Studies of specific environmental factors and immune dysfunction have provided limited insight into disease pathogenesis. There is ample evidence that these diseases are in part the result of genetic predisposition. The early search for candidate genes focused on genes involved in the regulation of immune function. Recent genome-wide searches reported several susceptibility loci for Crohn's disease and ulcerative colitis. The recent identification of the IBD1 gene (NOD2) with mutations that are associated with susceptibility to Crohn's disease will have a major impact on the understanding of the genetics of this disease.",
keywords = "Crohn's disease, Genetic counseling, Genetics, Inflammatory bowel disease, NOD2 gene, Ulcerative colitis",
author = "Amir Karban and Rami Eliakim and Brant, \{Steven R.\}",
note = "Funding Information: The Unit of Gastroenterology, Dr. V. Annese and Dr. A. Latiano have received funding from the National Health Ministry for studies in the field of the Genetics of Inflammatory Bowel Disease (RC0103GA29). ",
year = "2002",
month = oct,
day = "1",
language = "אנגלית",
volume = "4",
pages = "798--802",
journal = "Israel Medical Association Journal",
issn = "1565-1088",
publisher = "Israel Medical Association",
number = "10",
}