Genetics of inflammatory bowel disease

Amir Karban*, Rami Eliakim, Steven R. Brant

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The etiology of inflammatory bowel diseases, Crohn's disease and ulcerative colitis, is uncertain. Studies of specific environmental factors and immune dysfunction have provided limited insight into disease pathogenesis. There is ample evidence that these diseases are in part the result of genetic predisposition. The early search for candidate genes focused on genes involved in the regulation of immune function. Recent genome-wide searches reported several susceptibility loci for Crohn's disease and ulcerative colitis. The recent identification of the IBD1 gene (NOD2) with mutations that are associated with susceptibility to Crohn's disease will have a major impact on the understanding of the genetics of this disease.

Original languageEnglish
Pages (from-to)798-802
Number of pages5
JournalIsrael Medical Association Journal
Issue number10
StatePublished - 1 Oct 2002
Externally publishedYes


  • Crohn's disease
  • Genetic counseling
  • Genetics
  • Inflammatory bowel disease
  • NOD2 gene
  • Ulcerative colitis


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