Genetics of cognitive dysfunction in Parkinson's disease

Adina H. Wise, Roy N. Alcalay*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Presentation and progression of cognitive symptoms in Parkinson's disease are highly variable. PD is a genetically complex disorder with multiple genetic risk factors and understanding the role that genes play in cognitive outcomes is important for patient counseling and treatment. Currently, there are seven well-described genes that increase the risk for PD, with variable levels of penetrance: SNCA, LRRK2, VPS35, PRKN, PINK1, DJ1 and GBA. In addition, large, genome-wide association studies have identified multiple loci in our DNA which increase PD risk. In this chapter, we summarize what is currently known about each of the seven strongly-associated PD genes and select PD risk variants, including PITX3, TMEM106B, SNCA Rep1, APOɛ4, COMT and MAPT H1/H1, along with their respective relationships to cognition.

Original languageEnglish
Title of host publicationCognition in Parkinson's Disease
EditorsNandakumar S. Narayanan, Roger L. Albin, Roger L. Albin
PublisherElsevier B.V.
Number of pages32
ISBN (Print)9780323901642
StatePublished - Jan 2022
Externally publishedYes

Publication series

NameProgress in Brain Research
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855


  • Cognition
  • Cognitive impairment
  • Dementia
  • Genetics
  • GWAS
  • Parkinson's disease
  • Polymorphism
  • Variants


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