Genetics of cognitive dysfunction in Parkinson's disease

Adina H. Wise, Roy N. Alcalay*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Presentation and progression of cognitive symptoms in Parkinson's disease are highly variable. PD is a genetically complex disorder with multiple genetic risk factors and understanding the role that genes play in cognitive outcomes is important for patient counseling and treatment. Currently, there are seven well-described genes that increase the risk for PD, with variable levels of penetrance: SNCA, LRRK2, VPS35, PRKN, PINK1, DJ1 and GBA. In addition, large, genome-wide association studies have identified multiple loci in our DNA which increase PD risk. In this chapter, we summarize what is currently known about each of the seven strongly-associated PD genes and select PD risk variants, including PITX3, TMEM106B, SNCA Rep1, APOɛ4, COMT and MAPT H1/H1, along with their respective relationships to cognition.

Original languageEnglish
Title of host publicationCognition in Parkinson's Disease
EditorsNandakumar S. Narayanan, Roger L. Albin, Roger L. Albin
PublisherElsevier B.V.
Pages195-226
Number of pages32
Edition1
ISBN (Print)9780323901642
DOIs
StatePublished - Jan 2022
Externally publishedYes

Publication series

NameProgress in Brain Research
Number1
Volume269
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Keywords

  • Cognition
  • Cognitive impairment
  • Dementia
  • Genetics
  • GWAS
  • Parkinson's disease
  • Polymorphism
  • Variants

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