Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated with Cessation of Cocaine Use in Methadone Maintenance Patients with Opioid Addiction

Einat Peles, Orna Levran, Matthew Randesi, Jurg Ott, Mary Jeanne Kreek, Miriam Adelson

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: We have previously shown associations between 4 genetic variants in opioid and stress-related genes (OPRM1, NPYR1/NPYR5, NR3C1, and CRHBP) and prolonged abstinence from heroin without methadone maintenance treatment (MMT). We currently assessed the associations between these variants and MMT patients' characteristics. Methods: A non-selective group of 351 patients who stayed at least 1 year in their first admission to MMT were genotyped and their characteristics and substance in urine on admission and after 1 year were studied. Results: The proportions of patients with both cocaine and benzodiazepine abuse were reduced significantly after 1 year in MMT; however, cocaine abuse cessation was significantly associated with the non-carriers of the CRHBP (corticotrophin releasing hormone binding protein) SNP rs1500 minor C allele (GG genotype) (P = 0.0009, PBonferroni = 0.0221). More carriers of the 2 C alleles (CC genotype) than carriers of the GC and GG genotypes abused cocaine on admission (32.3% vs 19.7%, respectively, P = 0.0414, recessive model), and more of the C allele carriers (GC and CC genotypes) than non-carriers (GG genotype) abused cocaine after 1 year in MMT (25.7% vs 15.8%, respectively, P = 0.0334, dominant model). Abusers of benzodiazepine were more prevalent among carriers of the C allele compared with non-carriers on admission (60.6% vs 45.9%, respectively, P = 0.0080, dominant model), as well as after 1 year in MMT (50.9% vs 39.1%, respectively, P = 0.0362). Conclusions: Reduction in cocaine abuse among MMT patients may be mediated by a genetic effect in a stress-related gene (CRHBP SNP rs1500 minor C allele). Evaluations of larger samples, additional SNPs, and different populations are needed to support these findings.

Original languageEnglish
Pages (from-to)430-435
Number of pages6
JournalJournal of Addiction Medicine
Volume13
Issue number6
DOIs
StatePublished - 1 Nov 2019

Keywords

  • benzodiazepine
  • cocaine
  • CRH-binding protein gene
  • methadone maintenance treatment
  • SNP polymorphism
  • μ-opioid receptor

Fingerprint

Dive into the research topics of 'Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated with Cessation of Cocaine Use in Methadone Maintenance Patients with Opioid Addiction'. Together they form a unique fingerprint.

Cite this