Genetic Process in Resilience and Vulnerability and the Consequence of Abuse

M. Peskin*, G. Zalsman

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Child maltreatment and abuse represent the most adverse and stressful challenges that confront children in all societies that have been studied. These stressful events probably serve as pathogenic processes for the developing brain. Genetic polymorphisms have been found to interact with environmental adverse factors and result in psychopathology. New data show that the timing of the insult to the developing brain is crucial for the outcome. This effect has biological correlates in the structure of the brain in rodents and probably humans. Future studies will attempt to evaluate this in human subjects using imaging and molecular imaging techniques. Personalized treatments will follow.

Original languageEnglish
Title of host publicationPositive Mental Health, Fighting Stigma and Promoting Resiliency for Children and Adolescents
PublisherElsevier Inc.
Number of pages12
ISBN (Electronic)9780128044148
ISBN (Print)9780128043943
StatePublished - 27 Jun 2016


  • Abuse
  • Depression
  • Environment
  • Genetics
  • Maltreatment
  • Neglect
  • Resilience
  • Rodent
  • Timing
  • Vulnerability


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