Genetic ideology of dilated cardiomyopathy

Michael Arad*, Hadas Lahat, Dov Freimark

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Familial cardiomyopathies represent a substantial portion of idiopathic dilated cardiomyopathy in clinical practice. Diversity of clinical presentations and variability in penetrance lead to under-recognition of this disease entity as an inherited disorder. The mechanisms by which mutations in different genes perturb cardiac function and lead to pathologic remodeling help us understand the molecular pathways in disease pathogenesis and define the potential targets for therapeutic interventions. Appreciating when DCM is inherited might spare unnecessary diagnostic efforts and, instead, help give appropriate attention to the timely detection of subclinically affected family members. Establishing preventive therapy in asymptomatic family members showing early signs of cardiac dysfunction might prevent death and slow down progression to end-stage heart failure.

Original languageEnglish
Pages (from-to)392-396
Number of pages5
JournalIsrael Medical Association Journal
Volume7
Issue number6
StatePublished - Jun 2005

Keywords

  • Genetics
  • Heart failure
  • Idiopathic dilated cardiomyopathy

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