TY - JOUR
T1 - Genetic control of thymus size in inbred mice
AU - Peleg, Leah
AU - Nesbitt, Muriel N.
N1 - Funding Information:
The authors are, respectively, research biologist, Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel; and associate professor, Department of Biology, the University of California at San Diego, La Jolla, CA 92093. The studies described in this paper were done while the senior author was a postdoctoral fellow in the Department of Biology, University of California at San Diego. This work was supported by NIH grants CA 30082 and GM 29340 to M. N. Nesbitt. Please address reprint requests to Dr. Nesbitt. © 1984, American Genetic Association.
PY - 1984/3
Y1 - 1984/3
N2 - Differences exist among inbred mouse strains in the size of the thymus relative to overall body size. These differences are controlled by several genes acting in different phases of thymus development. After 50 days of age, there is an approximately 2-fold difference in thymus size between C57BL/6J and AKR/J, and other strains (A/J, DBA/2J, BALB/cJ, CBA/J, C3H/HeJ, 129/J, C57BL/10J, MA/MyJ). The C57BL/6J and AKR/J mice have the larger thymus, and this characteristic is dominant in F1 animals derived from C57BL/2J and A/J strains. Studies on recombinant inbred strains derived from C57BL/6J and DBA/2J (BXD strains), and C57BL/6J and A/J (AXB and BXA strains) indicate that this difference is controlled by alleles at one locus, which we have designated Tsz-1 (thymus size 1). In the immediate postnatal period (0-23 days), while the relative size of the thymus is increasing, the thymus size of C57BL/6J mice is large relative to that of A/J mice, but the A/J character is dominant during this period, and this difference appears to be controlled by two genes.
AB - Differences exist among inbred mouse strains in the size of the thymus relative to overall body size. These differences are controlled by several genes acting in different phases of thymus development. After 50 days of age, there is an approximately 2-fold difference in thymus size between C57BL/6J and AKR/J, and other strains (A/J, DBA/2J, BALB/cJ, CBA/J, C3H/HeJ, 129/J, C57BL/10J, MA/MyJ). The C57BL/6J and AKR/J mice have the larger thymus, and this characteristic is dominant in F1 animals derived from C57BL/2J and A/J strains. Studies on recombinant inbred strains derived from C57BL/6J and DBA/2J (BXD strains), and C57BL/6J and A/J (AXB and BXA strains) indicate that this difference is controlled by alleles at one locus, which we have designated Tsz-1 (thymus size 1). In the immediate postnatal period (0-23 days), while the relative size of the thymus is increasing, the thymus size of C57BL/6J mice is large relative to that of A/J mice, but the A/J character is dominant during this period, and this difference appears to be controlled by two genes.
UR - http://www.scopus.com/inward/record.url?scp=0021258567&partnerID=8YFLogxK
U2 - 10.1093/oxfordjournals.jhered.a109886
DO - 10.1093/oxfordjournals.jhered.a109886
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C2 - 6715864
AN - SCOPUS:0021258567
SN - 0022-1503
VL - 75
SP - 126
EP - 130
JO - Journal of Heredity
JF - Journal of Heredity
IS - 2
ER -