Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa

Eli Schwartz, Shay Bujanover, Kevin C. Kain

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to Kenya. Recurrent parasitemia occurred 30 days after directly observed therapy with a combination of atovaquone and proguanil. Treatment failure was confirmed by genetic fingerprinting and sequencing. The primary isolate had wild-type sequence of cytochrome b; however, the recrudescent isolate had a single mutation at position 268 (Tyr268Ser).

Original languageEnglish
Pages (from-to)450-451
Number of pages2
JournalClinical Infectious Diseases
Volume37
Issue number3
DOIs
StatePublished - 1 Aug 2003
Externally publishedYes

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