Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa

Eli Schwartz; Shay Bujanover; Kevin C. Kain

doi:10.1086/375599

Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa

Eli Schwartz, Shay Bujanover, Kevin C. Kain^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to Kenya. Recurrent parasitemia occurred 30 days after directly observed therapy with a combination of atovaquone and proguanil. Treatment failure was confirmed by genetic fingerprinting and sequencing. The primary isolate had wild-type sequence of cytochrome b; however, the recrudescent isolate had a single mutation at position 268 (Tyr268Ser).

Original language	English
Pages (from-to)	450-451
Number of pages	2
Journal	Clinical Infectious Diseases
Volume	37
Issue number	3
DOIs	https://doi.org/10.1086/375599
State	Published - 1 Aug 2003
Externally published	Yes

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title = "Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa",

abstract = "We report a case of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to Kenya. Recurrent parasitemia occurred 30 days after directly observed therapy with a combination of atovaquone and proguanil. Treatment failure was confirmed by genetic fingerprinting and sequencing. The primary isolate had wild-type sequence of cytochrome b; however, the recrudescent isolate had a single mutation at position 268 (Tyr268Ser).",

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note = "Funding Information: Financial support: This work was supported by the Canadian Institutes of Health Research (CIHR, MT-13721). K.C.K. is supported by a Career Scientist Award from the Ontario Ministry of Health and a Canada Research Chair (CIHR).",

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Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa

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