Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development

Tyler R. Huycke, Bess M. Miller, Hasreet K. Gill, Nandan L. Nerurkar, David Sprinzak, L. Mahadevan, Clifford J. Tabin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Gut smooth muscle patterning entails mechanical strain that orients the first layer circumferentially, and when formed, it spontaneously contracts to align the second layer longitudinally.

Original languageEnglish
Pages (from-to)90-105.e21
JournalCell
Volume179
Issue number1
DOIs
StatePublished - 19 Sep 2019

Keywords

  • Bmp
  • Hedgehog
  • cell orientation
  • differentiation
  • gut development
  • mechanical forces
  • morphogenesis
  • patterning
  • smooth muscle

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