Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development

Tyler R. Huycke; Bess M. Miller; Hasreet K. Gill; Nandan L. Nerurkar; David Sprinzak; L. Mahadevan; Clifford J. Tabin

doi:10.1016/j.cell.2019.08.041

Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development

Tyler R. Huycke, Bess M. Miller, Hasreet K. Gill, Nandan L. Nerurkar, David Sprinzak, L. Mahadevan, Clifford J. Tabin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Gut smooth muscle patterning entails mechanical strain that orients the first layer circumferentially, and when formed, it spontaneously contracts to align the second layer longitudinally.

Original language	English
Pages (from-to)	90-105.e21
Journal	Cell
Volume	179
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2019.08.041
State	Published - 19 Sep 2019

Funding

Funders	Funder number
National Institutes of Health	F31DK111059
National Institute of Child Health and Human Development	R01HD087234
Harvard Medical School

Keywords

Bmp
Hedgehog
cell orientation
differentiation
gut development
mechanical forces
morphogenesis
patterning
smooth muscle

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10.1016/j.cell.2019.08.041

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title = "Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development",

abstract = "Gut smooth muscle patterning entails mechanical strain that orients the first layer circumferentially, and when formed, it spontaneously contracts to align the second layer longitudinally.",

keywords = "Bmp, Hedgehog, cell orientation, differentiation, gut development, mechanical forces, morphogenesis, patterning, smooth muscle",

author = "Huycke, {Tyler R.} and Miller, {Bess M.} and Gill, {Hasreet K.} and Nerurkar, {Nandan L.} and David Sprinzak and L. Mahadevan and Tabin, {Clifford J.}",

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AU - Huycke, Tyler R.

AU - Miller, Bess M.

AU - Gill, Hasreet K.

AU - Nerurkar, Nandan L.

AU - Sprinzak, David

AU - Mahadevan, L.

AU - Tabin, Clifford J.

PY - 2019/9/19

Y1 - 2019/9/19

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AB - Gut smooth muscle patterning entails mechanical strain that orients the first layer circumferentially, and when formed, it spontaneously contracts to align the second layer longitudinally.

KW - Bmp

KW - Hedgehog

KW - cell orientation

KW - differentiation

KW - gut development

KW - mechanical forces

KW - morphogenesis

KW - patterning

KW - smooth muscle

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JO - Cell

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Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development

Abstract

Funding

Keywords

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