Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development

Tyler R. Huycke, Bess M. Miller, Hasreet K. Gill, Nandan L. Nerurkar, David Sprinzak, L. Mahadevan, Clifford J. Tabin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Gut smooth muscle patterning entails mechanical strain that orients the first layer circumferentially, and when formed, it spontaneously contracts to align the second layer longitudinally.

Original languageEnglish
Pages (from-to)90-105.e21
JournalCell
Volume179
Issue number1
DOIs
StatePublished - 19 Sep 2019

Funding

FundersFunder number
National Institutes of HealthF31DK111059
National Institute of Child Health and Human DevelopmentR01HD087234
Harvard Medical School

    Keywords

    • Bmp
    • Hedgehog
    • cell orientation
    • differentiation
    • gut development
    • mechanical forces
    • morphogenesis
    • patterning
    • smooth muscle

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