Genetic analyses of male breast cancer in Israel

R. S. Sverdlov, I. Barshack, R. B. Bar Sade, R. G. Baruch, G. Hirsh-Yehezkel, E. Dagan, M. Feinmesser, A. Figer, E. Friedman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Male breast cancer is a rare disorder, and little is known about the molecular mechanisms associated with the tumorigenic process. We genotyped 31 Jewish Israeli males with breast cancer for the predominant Jewish BRCA1 (185delAG, 5382InsC) and BRCA2 (6174delT) germline mutations: 11 individuals from high-risk families and 20 patients unselected for family history of cancer. Two patients of the high-risk group (18.2%) displayed germline mutations: one harbored the 185delAG BRCA1 mutation, and the other the 6174delT mutation in BRCA2. None of the unselected patients displayed any mutation. In 2 patients, complete mutation analysis of the BRCA2 gene did not reveal any disease-associated mutations. We conclude that the predominant Jewish germline mutations in BRCA1/BRCA2 contribute to male breast cancer in Israel, primarily in Ashkenazi individuals with a family history of cancer.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalGenetic Testing
Volume4
Issue number3
DOIs
StatePublished - 2000
Externally publishedYes

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