TY - JOUR
T1 - Genesis of ER Stress in Huntington's Disease
AU - Shenkman, Marina
AU - Eiger, Hagit
AU - Lederkremer, Gerardo Z.
N1 - Publisher Copyright:
© 2015 Marina Shenkman et al.
PY - 2015/7/15
Y1 - 2015/7/15
N2 - Recent research has identified ER stress as a major mechanism implicated in cytotoxicity in many neurodegenerative diseases, among them Huntington's disease. This genetic disorder is of late-onset, progressive and fatal, affecting cognition and movement. There is presently no cure nor any effective therapy for the disease. This review focuses on recent findings that shed light on the mechanisms of the advent and development of ER stress in Huntington's disease and on its implications, highlighting possible therapeutic avenues that are being or could be explored.
AB - Recent research has identified ER stress as a major mechanism implicated in cytotoxicity in many neurodegenerative diseases, among them Huntington's disease. This genetic disorder is of late-onset, progressive and fatal, affecting cognition and movement. There is presently no cure nor any effective therapy for the disease. This review focuses on recent findings that shed light on the mechanisms of the advent and development of ER stress in Huntington's disease and on its implications, highlighting possible therapeutic avenues that are being or could be explored.
KW - ER-associated degradation
KW - Huntington
KW - conformational disease
KW - neurodegenerative disease
KW - protein aggregation
KW - protein misfolding
KW - unfolded protein response
UR - http://www.scopus.com/inward/record.url?scp=84991007871&partnerID=8YFLogxK
U2 - 10.1515/ersc-2015-0007
DO - 10.1515/ersc-2015-0007
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AN - SCOPUS:84991007871
SN - 2300-4266
VL - 2
SP - 94
EP - 106
JO - Endoplasmic Reticulum Stress in Diseases
JF - Endoplasmic Reticulum Stress in Diseases
IS - 1
ER -