Genesis: Creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings

P. C. Sham; A. Sterne; S. Purcell; S. Cherny; M. Webters; F. Rijsdijk; P. Asherson; D. Ball; I. Craig; T. Eley; D. Goldberg; J. Gray; A. Mann; M. Owen; R. Plomin

doi:10.1375/136905200320565292

Genesis: Creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings

P. C. Sham^*, A. Sterne, S. Purcell, S. Cherny, M. Webters, F. Rijsdijk, P. Asherson, D. Ball, I. Craig, T. Eley, D. Goldberg, J. Gray, A. Mann, M. Owen, R. Plomin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

There is considerable evidence for a unitary and dimensional view of the genetic vulnerability to symptoms of anxiety and depression. The GENESiS (Genetic Environmental-Nature of Emotional States in Siblings) Study aims to use a multivariate approach to detect genetic loci that contribute to individual differences in this vulnerability dimension. The study used the UK General Practice Research Framework to generate a community-based sample of siblings. Questionnaire measures of anxiety/depression included the short form of the neuroticism scale from the revised Eysenck Personality Questionnaire (EPQ-N), the General Health Questionnaire (GHQ-12), and the anxious arousal and high positive affect subscales from the Mood and Anxiety Symptoms Questionnaire (MASQ-AA and MASQ-HPA). Genetic model-fitting of 2658 unselected sibships provided evidence for a single common genetic (familial) factor that accounted for a substantial proportion of the genetic variances and covariances of these four measures. Using the parameter estimates of this model, we constructed a composite index of this common genetic factor. This index, which has a sib correlation of 0.22, will be used as a quantitative phenotype in the molecular genetic phase of GENESiS.

Original language	English
Pages (from-to)	316-322
Number of pages	7
Journal	Twin Research
Volume	3
Issue number	4
DOIs	https://doi.org/10.1375/136905200320565292
State	Published - 2000
Externally published	Yes

Funding

Funders	Funder number
National Institutes of Health	EY-12562
Medical Research Council	G9700821

Keywords

Anxiety
Depression
Genetics
Neuroticism
Sibships
Vulnerability

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10.1375/136905200320565292

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Sham, P. C., Sterne, A., Purcell, S., Cherny, S., Webters, M., Rijsdijk, F., Asherson, P., Ball, D., Craig, I., Eley, T., Goldberg, D., Gray, J., Mann, A., Owen, M., & Plomin, R. (2000). Genesis: Creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings. Twin Research, 3(4), 316-322. https://doi.org/10.1375/136905200320565292

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title = "Genesis: Creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings",

abstract = "There is considerable evidence for a unitary and dimensional view of the genetic vulnerability to symptoms of anxiety and depression. The GENESiS (Genetic Environmental-Nature of Emotional States in Siblings) Study aims to use a multivariate approach to detect genetic loci that contribute to individual differences in this vulnerability dimension. The study used the UK General Practice Research Framework to generate a community-based sample of siblings. Questionnaire measures of anxiety/depression included the short form of the neuroticism scale from the revised Eysenck Personality Questionnaire (EPQ-N), the General Health Questionnaire (GHQ-12), and the anxious arousal and high positive affect subscales from the Mood and Anxiety Symptoms Questionnaire (MASQ-AA and MASQ-HPA). Genetic model-fitting of 2658 unselected sibships provided evidence for a single common genetic (familial) factor that accounted for a substantial proportion of the genetic variances and covariances of these four measures. Using the parameter estimates of this model, we constructed a composite index of this common genetic factor. This index, which has a sib correlation of 0.22, will be used as a quantitative phenotype in the molecular genetic phase of GENESiS.",

keywords = "Anxiety, Depression, Genetics, Neuroticism, Sibships, Vulnerability",

author = "Sham, {P. C.} and A. Sterne and S. Purcell and S. Cherny and M. Webters and F. Rijsdijk and P. Asherson and D. Ball and I. Craig and T. Eley and D. Goldberg and J. Gray and A. Mann and M. Owen and R. Plomin",

note = "Funding Information: This work was supported by MRC grant G9700821 and NIH grant EY-12562. We thank the general practitioners and the staff at the UK GP Research Framework who participated in this study.",

year = "2000",

doi = "10.1375/136905200320565292",

language = "אנגלית",

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Sham, PC, Sterne, A, Purcell, S, Cherny, S, Webters, M, Rijsdijk, F, Asherson, P, Ball, D, Craig, I, Eley, T, Goldberg, D, Gray, J, Mann, A, Owen, M & Plomin, R 2000, 'Genesis: Creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings', Twin Research, vol. 3, no. 4, pp. 316-322. https://doi.org/10.1375/136905200320565292

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T2 - Creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings

AU - Sham, P. C.

AU - Sterne, A.

AU - Purcell, S.

AU - Cherny, S.

AU - Webters, M.

AU - Rijsdijk, F.

AU - Asherson, P.

AU - Ball, D.

AU - Craig, I.

AU - Eley, T.

AU - Goldberg, D.

AU - Gray, J.

AU - Mann, A.

AU - Owen, M.

AU - Plomin, R.

N1 - Funding Information: This work was supported by MRC grant G9700821 and NIH grant EY-12562. We thank the general practitioners and the staff at the UK GP Research Framework who participated in this study.

PY - 2000

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N2 - There is considerable evidence for a unitary and dimensional view of the genetic vulnerability to symptoms of anxiety and depression. The GENESiS (Genetic Environmental-Nature of Emotional States in Siblings) Study aims to use a multivariate approach to detect genetic loci that contribute to individual differences in this vulnerability dimension. The study used the UK General Practice Research Framework to generate a community-based sample of siblings. Questionnaire measures of anxiety/depression included the short form of the neuroticism scale from the revised Eysenck Personality Questionnaire (EPQ-N), the General Health Questionnaire (GHQ-12), and the anxious arousal and high positive affect subscales from the Mood and Anxiety Symptoms Questionnaire (MASQ-AA and MASQ-HPA). Genetic model-fitting of 2658 unselected sibships provided evidence for a single common genetic (familial) factor that accounted for a substantial proportion of the genetic variances and covariances of these four measures. Using the parameter estimates of this model, we constructed a composite index of this common genetic factor. This index, which has a sib correlation of 0.22, will be used as a quantitative phenotype in the molecular genetic phase of GENESiS.

AB - There is considerable evidence for a unitary and dimensional view of the genetic vulnerability to symptoms of anxiety and depression. The GENESiS (Genetic Environmental-Nature of Emotional States in Siblings) Study aims to use a multivariate approach to detect genetic loci that contribute to individual differences in this vulnerability dimension. The study used the UK General Practice Research Framework to generate a community-based sample of siblings. Questionnaire measures of anxiety/depression included the short form of the neuroticism scale from the revised Eysenck Personality Questionnaire (EPQ-N), the General Health Questionnaire (GHQ-12), and the anxious arousal and high positive affect subscales from the Mood and Anxiety Symptoms Questionnaire (MASQ-AA and MASQ-HPA). Genetic model-fitting of 2658 unselected sibships provided evidence for a single common genetic (familial) factor that accounted for a substantial proportion of the genetic variances and covariances of these four measures. Using the parameter estimates of this model, we constructed a composite index of this common genetic factor. This index, which has a sib correlation of 0.22, will be used as a quantitative phenotype in the molecular genetic phase of GENESiS.

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KW - Genetics

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Genesis: Creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings

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Keywords

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