@article{43016adeb3cb4b2c9390dd7c2ac19aa7,
title = "Generation of auto-antibodies towards Alzheimer's disease vaccination",
abstract = "We developed a novel procedure to evoke anti-aggregating β-amyloid (Aβ) antibodies, using filamentous phages displaying only four amino acids EFRH of the β-amyloid peptide (AβP). This epitope was found to be the main regulatory site for fibril formation. For the first time, effective auto-antibodies have been obtained in guinea-pigs, which exhibit human identity in the AβP. Immunization through a phage-carrying epitope was found to be long-lasting, and no toxic effect caused by autoimmune response was detected in the challenged animal sections. These antibodies performed similarly to site-directed monoclonal antibodies and to antibodies raised against fibrillar Aβ in disaggregation of plaques, and may serve as the basis for developing an anti-Aβ vaccine.",
keywords = "Alzheimer's disease, EFRH phage, Vaccination",
author = "D. Frenkel and N. Kariv and B. Solomon",
note = "Funding Information: We would like to express our thanks to Dr G. Smith (University of Missouri), who generously provided us with the phage-peptide libraries, and to Natalia Posternak for performing the histological analysis. This work was supported by a grant from the Center for the Study of Emerging Diseases and by the Joan and Jaime Constantiner Institute for Molecular Genetics. ",
year = "2001",
month = mar,
day = "21",
doi = "10.1016/S0264-410X(00)00501-6",
language = "אנגלית",
volume = "19",
pages = "2615--2619",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier Ltd.",
number = "17-19",
}
