General pathophysiology of macular edema

Stefan Scholl, Albert Augustin*, Anat Loewenstein, Stanislao Rizzo, Baruch D. Kuppermann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Macular edema represents a common final pathway for many ocular diseases. Related ocular disorders include diabetic retinopathy, vascular occlusions, postsurgical situations, and uveitic diseases. The key pathophysiologic process is a breakdown of the blood-retinal barrier, normally preventing water movement in the retina, thus allowing fluid to accumulate in the retinal tissue via special water fluxes. Inflammatory processes and an increase in vascular permeability play a central role. Different mechanisms, complicated by ischemic conditions, interact in a complex network. Key factors are angiotensin II, prostaglandins, and the vascular endothelial growth factor. The various pathogenetic mechanisms and their contribution to the edema process are described in detail in this article.

Original languageEnglish
Pages (from-to)10-19
Number of pages10
JournalEuropean Journal of Ophthalmology
Volume21
Issue numberSUPPL.6
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • Angiotensin II
  • Blood-retinal barrier
  • Macular edema
  • Vascular endothelial growth factor

Fingerprint

Dive into the research topics of 'General pathophysiology of macular edema'. Together they form a unique fingerprint.

Cite this