TY - JOUR
T1 - Gene expression regulation mediated through reversible m 6 A RNA methylation
AU - Fu, Ye
AU - Dominissini, Dan
AU - Rechavi, Gideon
AU - He, Chuan
N1 - Funding Information:
The authors apologize to colleagues whose work was not cited owing to space limitation. They thank T. Pan, X. Wang, Y. Yue and J. Liu for discussion. C.H. is supported by the US National Institutes of Health grants GM071440 and the EUREKA grant GM088599. This work was also supported partly by grants from the Israel Science Foundation, the Flight Attendant Medical Research Institute (FAMRI) and the Israeli Centers of Research Excellence. S.F. Reichard contributed to editing of this manuscript.
PY - 2014/5
Y1 - 2014/5
N2 - Cellular RNAs carry diverse chemical modifications that used to be regarded as static and having minor roles in 'fine-tuning' structural and functional properties of RNAs. In this Review, we focus on reversible methylation through the most prevalent mammalian mRNA internal modification, N 6-methyladenosine (m 6 A). Recent studies have discovered protein 'writers', 'erasers' and 'readers' of this RNA chemical mark, as well as its dynamic deposition on mRNA and other types of nuclear RNA. These findings strongly indicate dynamic regulatory roles that are analogous to the well-known reversible epigenetic modifications of DNA and histone proteins. This reversible RNA methylation adds a new dimension to the developing picture of post-transcriptional regulation of gene expression.
AB - Cellular RNAs carry diverse chemical modifications that used to be regarded as static and having minor roles in 'fine-tuning' structural and functional properties of RNAs. In this Review, we focus on reversible methylation through the most prevalent mammalian mRNA internal modification, N 6-methyladenosine (m 6 A). Recent studies have discovered protein 'writers', 'erasers' and 'readers' of this RNA chemical mark, as well as its dynamic deposition on mRNA and other types of nuclear RNA. These findings strongly indicate dynamic regulatory roles that are analogous to the well-known reversible epigenetic modifications of DNA and histone proteins. This reversible RNA methylation adds a new dimension to the developing picture of post-transcriptional regulation of gene expression.
UR - http://www.scopus.com/inward/record.url?scp=84898814417&partnerID=8YFLogxK
U2 - 10.1038/nrg3724
DO - 10.1038/nrg3724
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AN - SCOPUS:84898814417
SN - 1471-0056
VL - 15
SP - 293
EP - 306
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 5
ER -