Gene expression in women conceiving spontaneously over the age of 45 years

Yuval Gielchinsky, Yoel Bogoch, Gideon Rechavi, Jasmine Jacob-Hirsch, Ninette Amariglio, David Shveiky, Michal Linial, Neri Laufer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objective: To examine gene expression profiles of women conceiving spontaneously after the age of 45. Design: Expression profiling by complementary DNA microarray analysis. Setting: University departments. Patient(s): Eight women 45 years or older (study group) who conceived spontaneously and were 6 months after their last delivery were compared with six women aged 45 years old (control group) who had their last delivery before the age of 30. Intervention(s): Blood samples were collected from each woman for RNA isolation from peripheral blood mononuclear cells (PBMC). Main Outcome Measure(s): Expression profiles of PBMC isolated from each woman were determined by using Affymetrix DNA microarray analysis covering about 15,000 identified genes. Result(s): Microarray of global gene expression revealed 671 genes that showed statistically significant differential expression between the study and control groups: 383 genes were overexpressed and 288 were underexpressed. The most significant functional groups defining these genes were: apoptosis, ubiquitination, and energy production. As many as 60 genes also participated in ovarian physiology. Conclusion(s): These observations suggest that extended fertility is associated with a unique ability to enrich cellular processes, leading to delayed ovarian senescence.

Original languageEnglish
Pages (from-to)1641-1650
Number of pages10
JournalFertility and Sterility
Volume89
Issue number6
DOIs
StatePublished - Jun 2008

Funding

FundersFunder number
SCCB
Sudarsky Center for Computational Biology
Women's Health Fund of Hadassah University Medical Center

    Keywords

    • Female fertility
    • gene expression
    • reproductive aging
    • spontaneous pregnancies

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