@article{b9b23e2bc0704a9c9a3f76309d43cbfe,
title = "Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy",
abstract = "Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in cancer cells. Alterations in chromosome copy number induce a wide variety of cellular stresses, including genome instability. Here, we show that cancer cells might exploit aneuploidy-induced genome instability and the resulting gene copy-number changes to survive under conditions of selective pressure, such as chemotherapy. Resistance to chemotherapeutic drugs was dictated by the acquisition of recurrent karyotypes, indicating that gene dosage might play a role in driving chemoresistance. Thus, our study establishes a causal link between aneuploidy-driven changes in gene copy number and chemoresistance and might explain why some chemotherapies fail to succeed.",
keywords = "aneuploidy, cancer, chemotherapy, drug resistance, genome instability",
author = "Ippolito, {Marica Rosaria} and Valentino Martis and Sara Martin and Tijhuis, {Andr{\'e}a E.} and Christy Hong and Ren{\'e} Wardenaar and Marie Dumont and Johanna Zerbib and Spierings, {Diana C.J.} and Daniele Fachinetti and Uri Ben-David and Floris Foijer and Stefano Santaguida",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = sep,
day = "13",
doi = "10.1016/j.devcel.2021.07.006",
language = "אנגלית",
volume = "56",
pages = "2440--2454.e6",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "17",
}