Abstract
Objectives: This study sought to investigate gender-related differences in patients with atrial fibrillation (AF) in Europe. Background: Gender-related differences may play a significant role in AF. Methods: We analyzed the data of 5,333 patients (42% female) enrolled in the Euro Heart Survey on Atrial Fibrillation. Results: Compared with men, the women were older, had a lower quality of life (QoL), had more comorbidities, more often had heart failure (HF) with preserved left ventricular systolic function (18% vs. 7%, p < 0.001), and less often had HF with systolic dysfunction (17% vs. 26%, p < 0.001). Among patients with typical AF symptoms (56% of women, 49% of men), there was no gender-related difference in the choice of rate or rhythm control. Among patients with atypical or no symptoms (44% of women, 51% of men), women less frequently underwent rhythm control (39% vs. 51%, p < 0.001) than did men. Women underwent less electrical cardioversion (22% vs. 28%, p < 0.001). Prescription of oral anticoagulants was identical (65%) in both genders. One-year outcome was similar except that women had a higher chance for stroke (odds ratio 1.83 in multivariable regression analysis, p = 0.019). Conclusions: Women with AF had more comorbidities, more HF with preserved systolic function, and a lower QoL than men. In the large group with atypical or no symptoms, women were treated appropriately more conservatively with less rhythm control than men. Women had a higher chance for stroke. Long-term QoL changes and other morbidities and mortality were similar.
| Original language | English |
|---|---|
| Pages (from-to) | 572-577 |
| Number of pages | 6 |
| Journal | Journal of the American College of Cardiology |
| Volume | 49 |
| Issue number | 5 |
| DOIs | |
| State | Published - 6 Feb 2007 |
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In: Journal of the American College of Cardiology, Vol. 49, No. 5, 06.02.2007, p. 572-577.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Gender-Related Differences in Presentation, Treatment, and Outcome of Patients With Atrial Fibrillation in Europe. A Report From the Euro Heart Survey on Atrial Fibrillation
AU - Dagres, Nikolaos
AU - Nieuwlaat, Robby
AU - Vardas, Panos E.
AU - Andresen, Dietrich
AU - Lévy, Samuel
AU - Cobbe, Stuart
AU - Kremastinos, Dimitrios Th
AU - Breithardt, Günter
AU - Cokkinos, Dennis V.
AU - Crijns, Harry J.G.M.
AU - Camm, A. John
AU - Davies, Wynn
AU - Capucci, Alessandro
AU - Olsson, Bertil
AU - Aliot, Etienne
AU - Le Heuzey, Jean Yves
AU - Santini, Massimo
AU - Manini, Malika
AU - Bramley, Claire
AU - Laforest, Vale´rie
AU - Taylor, Charles
AU - Del Gaiso, Susan
AU - Huber, Kurt
AU - De Backer, Guy
AU - Sirakova, Vera
AU - Cerbak, Roman
AU - Thayssen, Per
AU - Lehto, Seppo
AU - Blanc, Jean Jacques
AU - Delahaye, Franc¸ois
AU - Kobulia, Bondo
AU - Zeymer, Uwe
AU - Karlocai, Kristof
AU - Graham, Ian
AU - Shelley, Emer
AU - Behar, Shlomo
AU - Maggioni, Aldo
AU - Gonc¸alves, Lino
AU - Grabauskiene, Virginija
AU - Asmussen, Inger
AU - Deckers, Jaap
AU - Stepinska, Janina
AU - Mareev, Vyacheslav
AU - Vasiljevic, Zorana
AU - Riecansky, Igor
AU - Kenda, Miran F.
AU - Alonso, Angeles
AU - Lopez-Sendon, Jose´ Luis
AU - Rosengren, Annika
AU - Buser, Peter
AU - Okay, Tugrul
AU - Sychov, Oleg
AU - Fox, Kevin
AU - Schofield, Peter
AU - Simoons, Maarten
AU - Wood, David
AU - Battler, Alex
AU - Boersma, Eric
AU - Fox, Kim
AU - Komajda, Michel
AU - McGregor, Keith
AU - Mulder, Barbara
AU - Priori, Sylvia
AU - Ryde´n, Lars
AU - Vahanian, Alec
AU - Wijns, William
AU - Sanofi-Aventis,
AU - Grigoryan, S. V.
AU - Apetyan, I.
AU - Aroyan, S.
AU - Azarapetyan, L.
AU - Anvari, Anahit
AU - Gottsauner-Wolf, Michael
AU - Pfaffenberger, Stefan
AU - Aydinkoc, Kadriye
AU - Kalla, Karim
AU - Penka, Martina
AU - Drexel, Heinz
AU - Langer, Peter
AU - Pierard, Luc A.
AU - Legrand, Victor
AU - Blommaert, Dominique
AU - Schroeder, E.
AU - Mancini, Isabelle
AU - Geelen, P.
AU - Brugada, P.
AU - De Zutter, Marc
AU - Vrints, Christiaan
AU - Vercammen, Marc
AU - Morissens, Marielle
AU - Borisov, Boyanov
AU - Petrov, Valentin Asenov
AU - Marinova, Maria
AU - Assen, Alexandrova
AU - Goudev, Rachev
AU - Peychev, Yavor
AU - Stoyanovsky, Vassil
AU - Stoynev, Evgeni
AU - Kranjcevic, Stjepan
AU - Moutiris, Joseph
AU - Ioannides, Marios
AU - Evequoz, Dominique
AU - Spacilova, Jaroslava
AU - Novak, Miroslav
AU - Eisenberger, Martin
AU - Mullerova, Jolana
AU - Kautzner, Josef
AU - Riedlbauchova, Lucie
AU - Petru`, Jan
AU - Taborsky, Milos
AU - Cappelen, Helle
AU - Sharaf, Yasser A.
AU - Ibrahim, B. S.S.
AU - Tammam, Khalid
AU - Saad, Aly
AU - Elghawaby, Helmy
AU - Sherif, Hamed Zaky
AU - Farouk, Heba
AU - Mielke, Arlett
AU - Engelen, Markus
AU - Kirchhof, Paulus
AU - Zimmermann, Pia
AU - Aviles, F. Fernandez
AU - Rubio, Jeronimo
AU - Malpartida, F.
AU - Corona, M.
AU - Sanchez, Luis Tercedor
AU - Miguel, Jose
AU - Herrera, Lozano
AU - Quesada, Aurelio
AU - Garcia, Antonio J.Munoz
AU - Gonzalez, Carlos Sanchez
AU - Juango, M. Soledad Alcasena
AU - Berjon-Reyero, Jesus
AU - Alegret, Josep M.
AU - Fernandez, J. M.Cruz
AU - Carrascosa, Cesar
AU - Romero, Rosillo Antonio Fernandez
AU - Lara, Miguel Gonza´lez
AU - Sendon, Jose´ L.Lopez
AU - de Diego, Jose´ Juan Gomez
AU - Martin, Luis Sosa
AU - Irurita, Maria
AU - Guttierez, Norbero Herrera
AU - Rubio, Juan Ramon Siles
AU - Antorrena, Isabel
AU - Paves, Alicia Bautista
AU - Salvador, Antonio
AU - Orriach, Maria Dolores
AU - Garcia, A. Alonso
AU - Epelde, Francisco
AU - Martinez, Vicente Bertomeu
AU - Sanchez, Antonio Berruezo
AU - Galvez, Carlos Pinero
AU - Rivero, Rafael Fernandez
AU - Madrid, Antonio Hernandez
AU - Baron-Esquivias, Gonzalo
AU - Peinado, Rafael
AU - Guindal, Jose´ Antonio Gomez
AU - Vera, Tomas Ripoll
AU - Fernandez, Emilio Luengo
AU - Gayan, Ricardo
AU - Garcia, Javier
AU - Bodegas, Andres
AU - Lopez, Jesus Toril
AU - Florez, Julio Martinez
AU - Cabezas, Cristobal Lozano
AU - de Castroviejo, Eduardo Vazquez Ruiz
AU - Bellido, Juan Munoz
AU - Ruiz, Maria Eugenia
AU - Savolainen, Kirsti
AU - Nieminen, Markku
AU - Toivonen, Lauri
AU - Syvanne, Mikko
AU - Pietila, Mervi
AU - Galley, Daniel
AU - Beltra, Christine
AU - Gay, Alain
AU - Daubert, J. C.
AU - Lecocq, Guillaume
AU - Poulain, Christine
AU - Cleland, J. G.F.C.
AU - Shelton, Rhidian
AU - Choudhury, A.
AU - Abuladze, Gulnara
AU - Jashi, Irina
AU - Tsiavou, Anastasia
AU - Giamouzis, G.
AU - Kostopoulou, A.
AU - Tsoutsanis, Domproglou
AU - Stefanadis, C.
AU - Latsios, George
AU - Vogiatzis, Ioannis
AU - Gotsis, Alexandros
AU - Bozia, Paraskevi
AU - Karakiriou, Maria
AU - Koulouris, Spyridon
AU - Parissis, John
AU - Kostakis, George
AU - Kouris, Nikos
AU - Kontogianni, Dimitra
AU - Athanasios, Koutroubas
AU - Douras, Alexandros
AU - Tsanakis, Themistoklis
AU - Marketou, Mary
AU - Patsourakos, Nikolaos
AU - Czopf, Laszlo
AU - Halmosi, Robert
AU - Pre´da, Istvan
AU - Csoti, Eva
AU - Badics, Andrea
AU - Strasberg, Boris
AU - Freedberg, Nahum A.
AU - Katz, Amos
AU - Zalzstein, Eli
AU - Grosbard, Aviva
AU - Goldhammer, E.
AU - Nahir, Menachem
AU - Epstein, Menashe
AU - Vider, Ida
AU - Luria, David
AU - Mandelzweig, Lori
AU - Aloisi, Bruno
AU - Cavallaro, Alfio
AU - Antonielli, Emanuele
AU - Doronzo, Baldassarre
AU - Pancaldo, Diego
AU - Mazzola, Carlo
AU - Buontempi, Liliana
AU - Calvi, Valeria
AU - Giuffrida, Giuseppe
AU - Figlia, Antonino
AU - Ippolito, Francesco
AU - Gelmini, Gian Paolo
AU - Gaibazzi, N.
AU - Ziacchi, Virgilio
AU - De Tommasi, Francesco
AU - Lombardi, Federico
AU - Fiorentini, Cesare
AU - Terranova, Paolo
AU - Maiolino, Pietro
AU - Albunni, Muhamad
AU - Pinna-Pintor, Plinio
AU - Fumagalli, Stefano
AU - Masotti, Guilio
AU - Boncinelli, Lorenzo
AU - Rossi, Domenico
AU - Santoro, Giovanni Maria
AU - Fioranelli, Massimo
AU - Naccarella, Franco
AU - Maranga, Stefano Sdringola
AU - Lepera, Giovannina
AU - Bresciani, Barbara
AU - Seragnoli, Elena
AU - Forti, Mara Cantelli
AU - Cortina, Valentina
AU - Baciarello, Giacinto
AU - Cicconetti, Paolo
AU - Lax, Antonio
AU - Vitali, Federica
AU - Igidbashian, Diran
AU - Scarpino, Luisa
AU - Terrazzino, Sergio
AU - Tavazzi, Luigi
AU - Cantu, Francesco
AU - Pentimalli, Francesco
AU - Novo, Salvatore
AU - Coppola, Giuseppe
AU - Zingarini, Gianluca
AU - Ambrozio, Giuseppe
AU - Moruzzi, Paolo
AU - Callegari, Sergio
AU - Saccomanno, Gabriele
AU - Russo, Paolo
AU - Carbonieri, Emanuele
AU - Paino, Anna
AU - Zanetta, Marco
AU - Barducci, Enzo
AU - Cemin, Roberto
AU - Rauhe, Werner
AU - Pitscheider, Walter
AU - Meloni, Marina
AU - Marchi, Sergio Mariano
AU - Di Gennaro, Marco
AU - Calcagno, Sergio
AU - Squaratti, Paola
AU - Quartili, Francesco
AU - Bertocchi, Patrizia
AU - De Martini, Mario
AU - Mantovani, Giuseppe
AU - Komorovsky, Roman
AU - Desideri, Alessandro
AU - Celegon, Leopoldo
AU - Tarantini, Luigi
AU - Catania, Giuseppe
AU - Lucci, Donata
AU - Bianchini, Francesca
AU - Puodziukynas, Aras
AU - Kavoliuniene, Ausra
AU - Barauskiene, Vilija
AU - Aidietis, Audrius
AU - Barysiene, Jurate
AU - Vysniauskas, Vitas
AU - Zukauskiene, Irena
AU - Kazakeviciene, Nijole
AU - Georgievska-Ismail, Ljubica
AU - Poposka, Lidija
AU - Vataman, Eleonora
AU - Grosu, Aurel A.
AU - op Reimer, Wilma Scholte
AU - de Swart, Esther
AU - Lenzen, Mattie
AU - Jansen, Chris
AU - Brons, Ritzo
AU - Tebbe, Henriette
AU - van Hoogenhuyze, D. C.A.
AU - Veerhoek, M. J.
AU - Kamps, Maria
AU - Haan, D.
AU - van Rijn, Nitolanda
AU - Bootsma, Annette
AU - Baur, Leo
AU - van den, Adrie
AU - Fransen, Heidi
AU - Eurlings, Luc
AU - Meeder, Joan
AU - De Boer, M. J.
AU - Winter, Jobst
AU - Broers, Herman
AU - Werter, Chris
AU - Bijl, M.
AU - Versluis, Saskia
AU - Milkowska, Malgorzata
AU - Wozakowska-Kaplon, Beata
AU - Janion, Marianna
AU - Lepska, Lidia
AU - Swiatecka, Grazyna
AU - Kokowicz, Piotr
AU - Cybulski, Jacek
AU - Gorecki, Aleksandr
AU - Szulc, Marcin
AU - Rekosz, Jerzy
AU - Manczak, Rafal
AU - Wnuk-Wojnar, Anna Maria
AU - Trusz-Gluza, M.
AU - Rybicka-Musialik, Anna
AU - Myszor, Jaroslaw
AU - Szpajer, Michal
AU - Cymerman, Krzysztof
AU - Sadowski, Jerzy
AU - Sniezek-Maciejewska, Maria
AU - Ciesla-Dul, Mariola
AU - Gorkiewicz-Kot, Izabela
AU - Grodzicki, Tomasz
AU - Rewiuk, Krzysztof
AU - Kubik, Leszek
AU - Lewit, Jacek
AU - de Sousa, Joao Manuel Frazao Rodrigues
AU - Ferreira, Rafael
AU - Freitas, Antonio
AU - Morais, Joao Carlos Araujo
AU - Pires, Rui
AU - Gomes, M. J.Veloso
AU - Gago, Paula
AU - Candeias, Rui Alexandre C.
AU - Nunes, Luis
AU - Sa, Joao Vitor Miranda
AU - Ventura, Miguel
AU - de Oliveira, Mario
AU - Alves, Luis Brandao
AU - Bostaca, Ioan
AU - Olariu, Codin T.
AU - Dan, G. A.
AU - Dan, Anca
AU - Podoleanu, Cristian
AU - Frigy, Attila
AU - Georgescu, George I.M.
AU - Arsenescu, Catalina
AU - Statescu, Cristian
AU - Sascau, Radu
AU - Dimitrascu, Dan L.
AU - Rancea, Raluca
AU - Shubik, Yuri V.
AU - Duplyakov, Dmitry
AU - Shalak, Marina
AU - Danielyan, Marine
AU - Galyavich, Albert
AU - Zakirova, Venera
AU - Hatala, Robert
AU - Kaliska, Gabriela
AU - Kmec, Jan
AU - Zupan, Igor
AU - Tasie`, Jerneja
AU - Vokac, Damijan
AU - Edvardsson, Nils
AU - Poci, Dritan
AU - Gamra, Habib
AU - Denguir, Hichem
AU - Sepetoglu, Ahmet
AU - Arat-Ozkan, Alev
AU - Orynchak, Mariya
AU - Paliy, Elena
AU - Vakalyuk, I.
AU - Malidze, David
AU - Prog, Rostyslav
AU - Yabluchansky, Myckola Ivanovich
AU - Makienko, Nataliya Volodimirovna
AU - Potpara, Tatjana
AU - Knezevic, Sofija
AU - Randjelovic, Miomir
PY - 2007/2/6
Y1 - 2007/2/6
N2 - Objectives: This study sought to investigate gender-related differences in patients with atrial fibrillation (AF) in Europe. Background: Gender-related differences may play a significant role in AF. Methods: We analyzed the data of 5,333 patients (42% female) enrolled in the Euro Heart Survey on Atrial Fibrillation. Results: Compared with men, the women were older, had a lower quality of life (QoL), had more comorbidities, more often had heart failure (HF) with preserved left ventricular systolic function (18% vs. 7%, p < 0.001), and less often had HF with systolic dysfunction (17% vs. 26%, p < 0.001). Among patients with typical AF symptoms (56% of women, 49% of men), there was no gender-related difference in the choice of rate or rhythm control. Among patients with atypical or no symptoms (44% of women, 51% of men), women less frequently underwent rhythm control (39% vs. 51%, p < 0.001) than did men. Women underwent less electrical cardioversion (22% vs. 28%, p < 0.001). Prescription of oral anticoagulants was identical (65%) in both genders. One-year outcome was similar except that women had a higher chance for stroke (odds ratio 1.83 in multivariable regression analysis, p = 0.019). Conclusions: Women with AF had more comorbidities, more HF with preserved systolic function, and a lower QoL than men. In the large group with atypical or no symptoms, women were treated appropriately more conservatively with less rhythm control than men. Women had a higher chance for stroke. Long-term QoL changes and other morbidities and mortality were similar.
AB - Objectives: This study sought to investigate gender-related differences in patients with atrial fibrillation (AF) in Europe. Background: Gender-related differences may play a significant role in AF. Methods: We analyzed the data of 5,333 patients (42% female) enrolled in the Euro Heart Survey on Atrial Fibrillation. Results: Compared with men, the women were older, had a lower quality of life (QoL), had more comorbidities, more often had heart failure (HF) with preserved left ventricular systolic function (18% vs. 7%, p < 0.001), and less often had HF with systolic dysfunction (17% vs. 26%, p < 0.001). Among patients with typical AF symptoms (56% of women, 49% of men), there was no gender-related difference in the choice of rate or rhythm control. Among patients with atypical or no symptoms (44% of women, 51% of men), women less frequently underwent rhythm control (39% vs. 51%, p < 0.001) than did men. Women underwent less electrical cardioversion (22% vs. 28%, p < 0.001). Prescription of oral anticoagulants was identical (65%) in both genders. One-year outcome was similar except that women had a higher chance for stroke (odds ratio 1.83 in multivariable regression analysis, p = 0.019). Conclusions: Women with AF had more comorbidities, more HF with preserved systolic function, and a lower QoL than men. In the large group with atypical or no symptoms, women were treated appropriately more conservatively with less rhythm control than men. Women had a higher chance for stroke. Long-term QoL changes and other morbidities and mortality were similar.
UR - http://www.scopus.com/inward/record.url?scp=33846635888&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2006.10.047
DO - 10.1016/j.jacc.2006.10.047
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 17276181
AN - SCOPUS:33846635888
SN - 0735-1097
VL - 49
SP - 572
EP - 577
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 5
ER -