Gender differences in the expression of erythrocyte aggregation in relation to Bβ-fibrinogen gene polymorphisms in apparently healthy individuals

Einor Ben Assayag, Irena Bova, Shlomo Berliner, Hava Peretz, Sali Usher, Itzhak Shapira, Natan M. Bornstein

Research output: Contribution to journalArticlepeer-review

Abstract

An increased erythrocyte aggregation (EA) is associated with capillary slow flow, tissue hypoxemia and endothelial dysfunction. Fibrinogen is a major determinant in the formation of aggregated red blood cells. It has been suggested that the Bβ-fibrinogen -455G/A polymorphism is associated with erythrocyte hyperaggregability in men with coronary artery disease. The purpose of this study was to investigate the influence of the β-fibrinogen -455G/A polymorphism on erythrocyte aggregation in apparently healthy individuals. Plasma fibrinogen, red blood cell count, serum lipids, erythrocyte sedimentation rate, and the genotype of the Bβ-fibrinogen -455G/A polymorphism were examined in a cohort of 545 apparently healthy individuals and those with atherothrombotic risk factors. A whole blood erythrocyte aggregation test was performed by using a simple slide test and image analysis. In men, EA levels and plasma fibrinogen levels were significantly higher in subjects carrying the -455A allele compared to subjects with the -455 GG genotype. This association did not exist in women carrying the fibrogen -455A allele. The -455GA/AA men presented significantly higher correlation between the plasma fibrinogen concentrations and EA. This observations raises the prospect of possible change in the functional properties of the -455GA/AA fibrinogen, enhancing it ability to include EH. This study suggests that the Bβ-fibrinogen -455A allele is related to EH in men only. Putative mechanism could be hyperfibrinogenemia and a functional change in the fibrinogen molecule that alters its ability to interact with red blood cells and supports the aggregability of these cells.

Original languageEnglish
Pages (from-to)428-433
Number of pages6
JournalThrombosis and Haemostasis
Volume95
Issue number3
DOIs
StatePublished - Mar 2006

Keywords

  • Erythrocyte aggregation
  • Fibrinogen
  • Gene polymorphism

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