Geschlechtsunterschiede in der Mortalität von Statinanwendern im Alter von ≥80 Jahren

Translated title of the contribution: Gender differences in mortality among statin users aged 80 years or more

Dan Justo, Mark Tchernichovsky, Anjelika Kremer, Erel Joffe, Shany Sherman, Marina Ioffe, Haim Mayan

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Little is known about the prognosis associated with statin therapy and its gender differences in older adults aged ≥80 years. Objective: To study the mortality and survival associated with statin therapy and their gender differences in older adults aged ≥80 years. Method: This was a historical prospective study conducted at a tertiary medical center. The medical charts of all older adults aged ≥80 years who had been admitted to a single internal medicine department during 1 year were reviewed. All-cause 3‑year mortality and survival rates following hospital admission in men and in women using statins were investigated. Results: The final cohort included 216 patients: 122 (56.5%) women, mean age 85.3 ± 3.9 years. Overall, 66 (53.2%) women and 58 (46.8%) men used statins for 3 years or more following hospital admission. During this time 48 (39.3%) women and 48 (51.1%) men died. The all-cause 3‑year mortality rates were significantly lower only in women who had used statins compared with women who had not used statins (24.2% vs. 57.1%; relative risk = 0.2; 95% confidence interval 0.1–0.5; p < 0.0001). The 3‑year cumulative survival rates were significantly higher in women who had used statins as part of primary as well as secondary cardiovascular prevention (p < 0.0001 and p = 0.014, respectively). A Cox regression analysis showed that statin therapy was independently associated with low 3‑year cumulative mortality rates in women (hazard ratio=0.3; 95% confidence interval=0.1–0.6; p = 0.001). Conclusion: In older adults aged ≥80 years, statin therapy is associated with high 3‑year cumulative survival rates only in women.

Translated title of the contributionGender differences in mortality among statin users aged 80 years or more
Original languageGerman
Pages (from-to)880-886
Number of pages7
JournalZeitschrift fur Gerontologie und Geriatrie
Volume51
Issue number8
DOIs
StatePublished - 13 Dec 2018

Keywords

  • Cardiovascular disease
  • Observational study
  • Polypharmacy
  • Prognosis
  • Survival

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