Gender-dependent differences in latent inhibition following prenatal stress and corticosterone administration

Uri Shalev, Ina Weiner

Research output: Contribution to journalArticlepeer-review

Abstract

Latent inhibition (LI) indexes an organisms' ability to ignore irrelevant stimuli. Its disruption in the rat is considered to provide an animal model of the impaired ability to ignore irrelevant stimuli in schizophrenia. Given the importance of neurodevelopmental factors in the pathophysiology of schizophrenia, the present experiments investigated the effects of restraint, exposure to inescapable footshock and corticosterone administration during the last trimester of pregnancy, on the development of LI in the adult male and female offspring. Prenatal restraint had no effect on LI in the adult offspring of both sexes. Inescapable footshock exposure and corticosterone administration led to LI disruption in the male, but not the female offspring. These gender-dependent effects of prenatal treatments on LI suggest that it may provide a neurodevelopmental model of at least a sub-group of schizophrenia, in which environmental factors and gender are considered to play a significant role.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalBehavioural Brain Research
Volume126
Issue number1-2
DOIs
StatePublished - 29 Nov 2001

Keywords

  • Corticosterone
  • Environmental manipulations
  • Footshock
  • Latent inhibition
  • Prenatal stress
  • Restraint
  • Schizophrenia

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