GD2 and GD3 gangliosides as prognostic biomarkers in high grade serous ovarian cancer

Gabriel Levin*, Emad Matanes, Amber Yasmeen, Raanan Meyer, Melica Nourmoussavi Brodeur, Shannon Salvador, Susie Lau, H. Uri Saragovi, Walter Gotlieb

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Gangliosides GD2 and GD3 have been proposed to be of significance in diagnosis of ovarian masses. We aim to study serum GD2 and GD3 gangliosides as predictors of oncological outcomes among high grade serous (HGS) ovarian cancer (OC). Materials and methods: A retrospective study including biobanked serum samples of HGS OC treated between 2005 and 2016. Serum GD2 and GD3 concentrations were quantified using indirect ELISA and analyzed with respect to survival. Results: Sixty patients were included. Patients with GD3>12.8 ng/mL had shorter PFS when compared to patients with lower level; median 31 vs. 67 months, p = 0.005. Patients with GD2> 7.1 ng/mL had shorter median PFS than those with lower level of (23 vs. 52 months, p = 0.024.) Patients with GD3>14.5 ng/mL had shorter OS vs. patients with lower level (median 31 vs. 70 months, p = 0.002). In a Cox regression, following adjustment for age, CA-125, disease stage and age, serum elevated GD3 was independently associated with short PFS (adjusted hazard ratio 2.0, 95 % CI 1.1–3.8, p=.024). In a separate Cox regression, elevated GD2 was independently associated with PFS (adjusted hazard ratio3.0 (1.2–7.7). p=.019. High serum GD3 and GD2 were independently associated with short OS as well. Conclusions: High levels of serum GD2 and GD3 in HGS OC were associated with shorter PFS and OS. GD3 is superior to GD2 as a biomarker for prognosis.

Original languageEnglish
Article number102860
JournalJournal of Gynecology Obstetrics and Human Reproduction
Volume54
Issue number1
DOIs
StatePublished - Jan 2025
Externally publishedYes

Funding

FundersFunder number
Israel Cancer Research Fund
Gloria's Girls Fund
Canadian Institutes of Health Research202104PQQ

    Keywords

    • Biomarker
    • Diagnostic test
    • Elisa
    • Ganglioside
    • Liquid biopsy
    • Ovarian cancer

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