Gastrointestinal tract as a target organ for orally administered insulin

Naim Shehadeh*, Igor Sukhotnik, Raanan Shamir

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The intestine is not considered to be a classic target tissue for insulin. Recent in vitro and in vivo experiments suggest that intestinal as well as systemic effects are observed following oral administration of insulin. Local effects include enhancement of intestinal growth, cell maturation, enzyme expression, gut adaptation after intestinal resection and reduction of intestinal permeability. Systemic effects, at least in animal models, include favorable effects on blood glucose and lipid profile and on the prevention of autoimmunity and attenuating the atherosclerosic process.

Original languageEnglish
Pages (from-to)276-281
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Issue number3
StatePublished - Sep 2006
Externally publishedYes


  • Gastroentistinal tract
  • Maturation
  • Oral insulin


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