Gastrointestinal stromal sarcomas

D. Lev, Y. Kariv, J. Issakov, H. Merhav, E. Berger, O. Merimsky, J. M. Klausner, M. Gutman

Research output: Contribution to journalArticlepeer-review


Background: Gastrointestinal stromal sarcomas are a rare group of malignancies originating in the bowel wall. Methods: The treatment of 12 patients with gastrointestinal stromal sarcoma who underwent operation between 1994 and 1998 was reviewed. Results: Eight tumours originated in the stomach; others were in the small bowel or rectum. Five of the tumours were of myogenic origin, two were gastrointestinal autonomic nerve tumours, one was a mixed neural-myoid tumour, and four could not be differentiated. Complete resection was possible in ten patients; in two of the ten en bloc resection of adjacent organs was required to ensure adequate margins. The tumours in the remaining two patients were irresectable because of diffuse intra-abdominal metastatic disease. All patients who underwent complete resection were alive after 4-48 (median 14) months. Two of the ten patients developed recurrence, which was reresected completely. The patients with metastatic disease died less than 1 year after operation. Conclusion: Aggressive surgical resection, achieving complete resection, can lead to prolongation of life and may be a potential cure for patients with gastrointestinal stromal sarcoma.

Original languageEnglish
Pages (from-to)545-549
Number of pages5
JournalBritish Journal of Surgery
Issue number4
StatePublished - 1999
Externally publishedYes


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