TY - CHAP
T1 - Gastric Dysfunction in Parkinson's Disease
AU - Rozenberg, Ayal
AU - Gurevich, Tanya
AU - Giladi, Nir
AU - Korczyn, Amos D.
PY - 2013
Y1 - 2013
N2 - Parkinson's disease (PD) is a degenerative illness affecting the central, autonomic, and the enteric nervous systems (ENS). Neuropathological changes have been described in all parts of the ENS in PD patients. Gastric dysfunction is common in PD patients and includes delayed gastric emptying (gastroparesis), early satiety, anorexia, abdominal fullness, nausea, and vomiting. Gastric dysfunction may impair drug absorption and thus contribute to motor fluctuations in PD. Moreover, antiparkinsonian medications themselves may exacerbate gastric dysfunction. To date, there is no satisfactory drug treatment for gastroparesis, and the clinician will need considerable creativity for planning therapeutic management to help the PD patient overcome this disabling syndrome and its consequences. Dietetic interventions, together with prokinetic medications, are recommended. Gastrostomy or jejunostomy feeding tubes should also be considered for patients with severe gastroparesis.
AB - Parkinson's disease (PD) is a degenerative illness affecting the central, autonomic, and the enteric nervous systems (ENS). Neuropathological changes have been described in all parts of the ENS in PD patients. Gastric dysfunction is common in PD patients and includes delayed gastric emptying (gastroparesis), early satiety, anorexia, abdominal fullness, nausea, and vomiting. Gastric dysfunction may impair drug absorption and thus contribute to motor fluctuations in PD. Moreover, antiparkinsonian medications themselves may exacerbate gastric dysfunction. To date, there is no satisfactory drug treatment for gastroparesis, and the clinician will need considerable creativity for planning therapeutic management to help the PD patient overcome this disabling syndrome and its consequences. Dietetic interventions, together with prokinetic medications, are recommended. Gastrostomy or jejunostomy feeding tubes should also be considered for patients with severe gastroparesis.
KW - Gastric emptying
KW - Gastric function
KW - Motor fluctuations
KW - Parkinson's disease
KW - l-Dopa pharmacokinetics
UR - http://www.scopus.com/inward/record.url?scp=84899441787&partnerID=8YFLogxK
U2 - 10.1007/978-1-60761-429-6_9
DO - 10.1007/978-1-60761-429-6_9
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AN - SCOPUS:84899441787
SN - 9781607614289
T3 - Milestones in Drug Therapy
SP - 145
EP - 154
BT - Parkinson's Disease and Nonmotor Dysfunction
PB - Springer Basel
ER -